自噬与2型糖尿病
被引量:1
Autophagy and type 2 diabetes
摘要
自噬与2型糖尿病的关系是目前一个新兴研究领域。研究发现,自噬与胰岛β细胞功能缺陷和胰岛素抵抗均可能相关,本文对这方面研究进展进行综述和讨论。
出处
《军医进修学院学报》
CAS
2012年第9期992-994,共3页
Academic Journal of Pla Postgraduate Medical School
基金
北京市首都医学科研发展基金联合攻关课题(2003-1009)~~
参考文献4
-
1Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia : inhibition of FoxO 1-dependent expression of key autophagy genes by insulin [ J ] . J Biol Chem, 2009, 284 ( 45 ) : 31484-31492.
-
2Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet [ J ] . Cell Metab, 2008, 8 ( 4 ) : 325-332.
-
3Jung HS, Chung KW, Won KJ, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia [ J ] . Cell Metab, 2008, 8 ( 4 ) : 318-324.
-
4Song B, Seheuner D, Ron D, et al. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes[ J ]. J Clin Invest, 2008,118( 10 ): 3378-3389.
同被引文献34
-
1Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress:cross-talk and redox signalling[J]. Biochem J,2012,441(2):523.
-
2Mizushima N. Autophagy:process and function[J]. Genes Dev,2007,21(22):2861.
-
3Mizushima N, Levine B, Cuervo A M, et al. Autophagy fights disease through cellular self-digestion[J].Nature, 2008:451(7182):1069.
-
4Choi S E, Lee S M, Lee Y J, et al. Protective role of autophagy in palmitate-induced INS-1 beta-cell death[J]. Endocrinology,2009,150(1):126.
-
5Quan W, Lee M S. Role of autophagy in the control of body metabolism[J]. Endocrinol Metab (Seoul),2013,28(1):6.
-
6He C, Bassik M C, Moresi V, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis[J]. Nature,2012,481(7382):511.
-
7Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells[J]. Diabetologia,2009,52(6):1083.
-
8Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets:evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated[J]. Diabetes,2002,51(5):1437.
-
9Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet[J]. Cell Metab,2008,8(4):325.
-
10Marsh B J, Soden C, Alarcon C, et al. Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells[J]. Mol Endocrinol,2007,21(9):2255.
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-
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-
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-
1牟玲.灯盏细辛注射液治疗不稳定型心绞痛38例的疗效观察[J].泸州医学院学报,2003,26(6):533-534. 被引量:4
-
2李光辉,黄醒华.代谢综合征与妊娠[J].中华围产医学杂志,2007,10(2):125-128. 被引量:2
-
3苏启棠.新兴县40年急性传染病发病情况分析[J].肇庆医药,1991(1):14-16.
-
4黄子波,罗宇欢,李观庆.瑞替普酶和阿替普酶溶栓治疗急性心肌梗死的对比研究[J].当代医学,2014,20(19):138-138. 被引量:5
-
5周伟荣,黄莉.苯那普利治疗早期糖尿病肾病的观察[J].临床医学,2001,21(9):38-39.
-
6焦坤,冯玉宝,苏平.同型半胱氨酸与血压变异性的关系研究[J].世界最新医学信息文摘,2016,0(8):55-56. 被引量:2
-
7朱建宇.糖尿病及其运动疗法[J].考试周刊,2008,0(32):237-238.
-
8牟严艳.胰岛素强化治疗初发2型糖尿病的远期效果[J].浙江临床医学,2012,14(3):298-299.
-
9刘洋,孟雁.2型糖尿病蛋白质组学研究进展[J].生理通讯,2008,27(6):162-165.
-
10张腊梅,张春华,陈琰,陈雪.2型糖尿病糖化血红蛋白达标组与不达标组血脂浓度比较[J].交通医学,2006,20(5):524-524. 被引量:7