多时段血糖控制对糖尿病心血管病变转归及与TNF-α和IGF-1关系的研究

Study on the relationship between multi-time blood glucose control and TNF-α,IGF-1 and disease turnover of diabetic cardiovascular disease

目的探讨多时段血糖控制在糖尿病心血管病变治疗中的作用。方法对76例确诊为2型糖尿病的病人每月进行多时段血糖监测,并根据结果进行降糖药物调整使血糖稳定;而对照组的35例患者则根据空腹及早餐后血糖监测调整降糖药物。所有病人定期检查血糖、血压及HbA1c、心电图、心脏B超、动态心电图等;所有观察对象进行受试前后TNF-α和IGF-1的检测。结果多时段血糖控制组其心血管病变改善及稳定的阳性率高于对照组,而发生心血管病变加重的阳性率低于对照组;多时段血糖监测与控制的糖尿病病人2年后TNF-α和IGF-1水平低于对照组(P<0.05)。结论多时段血糖控制可延缓2型糖尿病心血管病变的发生和发展,并对心血管病变有改善作用,能降低TNF-α和IGF-1的表达。

Objective To explore the effect of multi-time blood glucose monitoring on diabetic cardiovascular disease. Method 76 diagnosed type 2 diabetic patients of the multi-time control group were underwent multi-time glucose monitoring every month and adjusted hypoglycemic drug to stable blod glucose, while 35 patients of the control group were adjusted their hypoglycemic drug according only to fasting and postprandial blood glucose. All patients were regularily measured with blood glucose, blood pressure, HbAll, ECG, cardiac B ultrasound, and DCG. TNF-α and IGF-1 of the two groups before and after study were measured as well. Result The rates of improvement and stability of diabetic cardiovascular disease in multi-time group were higher than those in control group, and their level of TNF-α and IGF-1 were lower than those in control group. Conclusion Multi-time blood glucose control can defer the onset of and development of complication of diabetic cardiovascular disease in type 2 diabetes, improve cardiovascular disease, and decrease the expression of TNF-α and IGF-1.