高温与香烟联合对大鼠早期胚胎致畸作用的研究

Studies on Teratogenic Effects of Hyperthermia and Smoke of the Cigarette in Early Embryos of the Rat

为了探讨高温与香烟联合对胚胎的毒性和致畸作用 ,用高温 ( 40、4 1、4 2、4 3℃ )及香烟烟雾水溶物联合处理怀孕的大鼠。结果表明 ,高温与香烟联合可加强胚胎的致畸作用 ,并与温度、香烟浓度和高温持续时间明显相关 ,当持续 3分钟的高温与香烟联合 ,胚胎致畸率达 70 %以上 ,与单独高温组、单独给烟组有明显差异 (P >0 0 1 ) ,并具有协同效应。结果提示 ,持续高温与香烟联合有明显的胚胎毒性和致畸作用。

To reseach the toxic and teratogenicity of hyperthermia combined with cigarette smoking in early embryos of rat Pregnant rats were exposed to hyperthermia or aqueous solution of soluble cigarette smoking and to the combined with hyparthermia and cigarette somking.The absorption rate,death rate and teratogenic rate of the rat embryo were examined,and measured with experimental teratological methods on the day twenty of gestation.The results showed that the hyperthermia combined with cigarette smoking could enhance the teratogenic and toxic effects of the rat embryos,which is related with the temperture,the sustained time of the hyperthermia and the comcentration of the cigarette smoking.The rats were put into hyperthermia(42℃)for three minutes,the result indicated that the hyperthermia combined with cigarette smoking their teratogenic rate was more than 70% and there was a significant difference compared with the rate of those only in single hyperthermia of single cigarette smoke.It suggests that the sustained hyperthermia combined with cigarette smoking can lead obvious toxic and teratognic effects of the rat embryos.