血浆N末端B型利钠肽原对急性冠脉综合征患者近期预后的预测价值(英文)

Predictive value of amino-terminal pro-B-type natriuretic peptide on short term prognosis in patients with acute coronary syndrome

目的:评价血浆N末端B型利钠肽原(NT-proBNP)对急性冠脉综合征(ACS)患者近期预后的预测价值。方法:连续检测600例住院的ACS患者的血浆NT-proBNP浓度。依据住院期间患者有无心血管事件(心源性死亡、心源性休克、充血性心力衰竭)分为事件组(108例)和无事件组(n=492例),比较两组NT-proBNP水平,并用回归分析法判断血浆NT-proBNP是否为ACS患者近期心血管事件的独立预测因素。结果:事件组血浆NT-proBNP浓度显著高于无事件组[1361.2(965.3,2088.6)pmol/L比605.7(274.5,1177.8)pmol/L,P<0.01]。Lo-gistic多元逐步回归分析表明,血浆NT-proBNP是ACS患者近期发生心血管事件的独立预测因素(OR=1.000,P=0.000)。结论:入院时血浆N末端B型利钠肽原是急性冠脉综合征患者近期预后的独立预测因素。

Objective ： To evaluate the predictive value of plasma amino-terminal pro-B-type natriuretic peptide（NTproBNP） on short term prognosis in patients with acute coronary syndrome（ACS）.Methods ： Plasma NT-proBNP levels were measured in ACS patients within 24 h after admission with ELISA method.The 600 ACS patients were divided into two groups ： event group（n=108） and no-event group（n=492） according to occurrence of cardiovascular events（including cardiac death,cardiac shock and heart failure）.The NT-proBNP levels were compared between two groups.Single factor and multiple factor Logistic regression analyses were used to evaluate if NT-proBNP was an independent predictor for short term prognosis.Results ： The plasma NT-proBNP levels of event group were significantly higher than those of no-event group [ 1361.2（965.3,2088.6） pmol / L vs.605.7（274.5,1177.8） pmol / L,P0.01 ].Multiplefactor Logistic regression analyses demonstrated that plasma NT-proBNP was an independent predictor for short term prognosis（OR=1.000,P0.01） in ACS patients.Conclusion ： Plasma NT-proBNP was an independent predictor for short term prognosis in ACS patients.