急性心肌梗死患者PCI后白介素-6与10的变化及其意义

Changes and its significance of serum interleukin-6 and interleukin-10 in AMI patients after percutaneous coronary intervention

目的:探讨血白细胞介素-6(IL-6)及IL-10浓度在急性心肌梗死(AMI)患者急诊介入治疗后的变化及其意义。方法:选择60例行急诊经皮冠状动脉介入术(PCI)治疗患者(AMI组)和30例冠状动脉造影正常者(正常对照组),采用酶联免疫吸附法(ELISA)检测PCI术后第1d及第7d患者的血清IL-6及IL-10的含量,并与正常对照组进行比较分析。结果:与正常对照组相比,AMI组PCI术后患者的血清IL-6[(110.34±26.01)pg/ml比(156.97±68.58)pg/ml]、IL-10[(18.21±4.0)ng/ml比(19.94±10.01)ng/ml]水平及IL-6/IL-10比值[(6.73±2.04)比(10.99±8.24)]明显升高(P<0.05),且IL-6与IL-10呈正相关(r=0.44,P<0.05);结论:急性心肌梗死后血清白细胞介素-6、白细胞介素-10水平升高,可能参与急性心肌梗死的发生和发展。

Objective：To explore changes of interleukin（IL）-6 and IL-10 concentration and its clinical significance in patients with acute myocardial infarction（AMI） after emergency percutaneous coronary intervention（PCI）.Methods：A total of 60 AMI patients undergoing emergency PCI（AMI group） and 30 subjects with normal coronary angiography（normal control group） were enrolled in the study.Enzyme linked immunosorbent assay（ELISA） was used to measure serum concentrations of IL-6 and IL-10 in AMI patients on first and seventh day after PCI,and the results were compared with those of normal control group.Results： Compared with normal control group,there were significant increase in serum levels of IL-6 [（110.34±26.01） pg ml vs.（156.97±68.58） pg ml],IL-10 [（18.21±4.0） ng ml vs.（19.94±10.01） ng ml]and ratio of IL-6 IL-10 [（6.73±2.04） vs.（10.99±8.24）]in AMI group on seventh day after PCI（P0.05 all）.The IL-6 level was positively correlated with that of IL-10（r=0.44,P0.05）.Conclusion： Levels of interleukin-6 and interleukin-10 increase after acute myocardial infarction,they may participate in occurrence and development of acute myocardial infarction.