幽门螺杆菌与冠心病的关系

Relationship between Helicobacter pylori and coronary heart disease

目的:探讨幽门螺杆菌(HP)与冠心病(CHD)的关系。方法:268例冠心病不稳定型心绞痛患者均进行14C试验,根据检查结果分为HP阳性组(114例)和HP阴性组(159例),每组患者均接受冠心病不稳定型心绞痛的标准治疗方案,分别观察两组患者3个月内心绞痛发生需要入院的情况与一年内心肌梗死发生率。结果:3个月内,两组因心绞痛再入院率无显著差异(χ2=0.76,P>0.05);一年内HP阳性组心肌梗塞发生率明显高于HP阴性组(5.3%比0.6%,P<0.05)。结论:幽门螺杆菌与冠心病不稳定型心绞痛患者发生心肌梗死有一定关系,但是具体作用机制还需要进一步探讨。

Objective：To study the clinical significance detecting Helicobacter pylori（HP）in patients with coronary heart disease （CHD）. Methods：According to results of14C test, a total of 268 cases with unstable angina pectoris （UAP） of CHD were divided into HP positive group （n=114） and HP negative group （n=159）. All patients of the two groups received standard treatment of CHD. Rehospitalization rate caused by angina pectoris within three months and incidence rate of myocardial infarction within one year were observed and compared in two groups. Results：There was no significant difference in rehospitalization rate caused by angina pectoris within three months between two groups （χ2=0.76,P0.05）; Incidence rate of myocardial infarction within one year in HP positive group was significantly higher than that of HP negative group （5.3% vs. 0.6%, P0.05）. Conclusion： There is a certain relationship between Helicobacter pylori and incidence of myocardial infarction in patients with coronary heart disease,but understanding its true mechanism needs further study.