替罗非班对急性心肌梗死急诊冠状动脉介入治疗冠状动脉微循环的影响

Effect of tirofiban hydrochloride on coronary microcirculation of acute myocardial infarction in emergency percutaneous coronary interventional therapy

目的探讨并评价采用替罗非班对心肌梗死患者急诊实施冠状动脉介入治疗微循环产生的影响。方法将我院收治的ST段抬高性急性心肌梗死患者62例随机分成观察组32例与对照组30例,对比分析两组患者的临床状况、心电图ST段回落幅度、主要心脏不良事件及住院期间出血事件发生率等。结果观察组1.5 h心电图ST段回落幅度大于对照组,治疗前后比较差异具有统计学意义(P<0.05);观察组发生牙龈出血4例,对照组3例,两组均未见颅内出血与血小板减少症。术后观察组凝血因子TF与vWF均低于对照组,两组比较差异具有统计学意义(P<0.05),两组患者的PT与AFTT之间差异无统计学意义。结论采用替罗非班对心肌梗死患者急诊实施冠状动脉介入手术能够争取更多时间,以防止大量心肌细胞发生永久性坏死,有效解除心肌微循环障碍,明显降低无复流现象。

Objective To evaluate the effect of tirofiban hydrochloride on coronary microcirculation of acute myocardial infarction（AMI）in emergency percutaneous coronary interventional therapy.Methods 62 AMI patients with ST segment elevation were divided into observation group（32 cases） and control group（30 cases）,the clinical status,the drop rate of electrocardiogram ST segment,major adverse cardiac events and bleeding events were compared between the two groups.Results After treatment,1.5 h ST segment of electrocardiogram of the observation group fell,more than those of control group（P0.05）;There were 4 cases of gingival hemorrhage in observation group while 3 cases in the control group.There was no intracranial hemorrhage and thrombocytopenia in the two groups.TF and vWF of observation group were lower than those of the control group（P0.05）,PT and AFTT of the two groups had no obvious difference（P0.05）.Conclusion Tirofiban hydrochloride has better effects on coronary microcirculation of acute myocardial infarction in emergency percutaneous coronary interventional therapy.