早期集束化抢救急性左心功能衰竭疗效分析

Clinical curative value of early stage bundle therapy in acute left heart failure

目的观察早期集束化抢救措施治疗急性左心功能衰竭患者的疗效。方法 174例急性左心功能衰竭的患者随机分为2组,所有患者进行强心、利尿、扩张血管、镇静等常规抢救治疗,A组(69例)采取常规抢救,维持血压>100/60 mmHg;B组(105例)进行早期集束化抢救治疗。20～30 min内给予静脉注射重组人脑利钠肽(rhBNP),注射冲击量1.5μg/kg,60 s匀速静脉注射,之后0.007 5μg/(kg.min)维持静脉注射48 h,维持血压>100/60 mmHg;给予机械通气,维持氧饱和度90%以上。观察抢救2、24 h的成功率和24 h死亡率。结果 A组与B组患者2、24 h抢救成功率和24 h死亡率分别为81.16%vs.91.51%、89.86%vs.96.23%、7.25%vs.1.94%,两组比较,差异有统计学意义(P<0.05)。结论早期集束化抢救措施可以改善急性左心功能衰竭患者抢救成功率和预后。

Objective To observe the effect of early stage bundle therapy on acute left heart failure.Methods 174 patients with acute left heart failure were divided into two groups：Group A（n=69） was treated with routine methods,such as cardiac tonic,diuresis,expansion blood vessels and calm;Group B（n=105） was treated with 24 h early stage bundle therapy,including routine methods and recombination human brain natriuretic peptides,machine ventilation.Results The success rate after treatment for 2 h and 24 h and the 24 h mortality rate were 81.16% vs.91.51%,89.86% vs.96.23%,7.25% vs.1.94% respectively,there were significant differences between the two groups（P0.05）.Conclusion Early stage bundle therapy could improve curative rate and prognosis of acute left heart failure.