抑郁症患者血清脑源性神经营养因子水平及其相关因素

An analysis of serum levels of BDNF and related factors in depressive patients

目的探讨抑郁症患者血清脑源性神经营养因子水平及其相关因素，为防治抑郁症提供重要依据。方法采用酶联免疫吸附法和汉密尔顿抑郁量表分别测定40例抑郁症患者（患者组）的血清BDNF水平和抑郁严重程度，并与49名正常者（对照组）进行对比分析。结果患者组治疗前血清BDNF水平明显降低，与对照组比较差异有统计学意义（P〈0．01）。患者组治疗8周末血清BDNF水平明显升高，HAMD总分明显降低，与治疗前比较差异有统计学意义（P〈0．05）。患者组治疗前后血清BDNF水平与性别及年龄均呈负相关，差异具有统计学意义（P〈0．05），与受教育程度、病程及HAMD总分比较无统计学意义（P〉0．05）。结论抑郁症患者存在血清BDNF水平的下降，抗抑郁治疗可改善抑郁症状，并显著提高血清BDNF水平。

Objective To explore the serum＇levels of Brain--derived neurotrophic factor （BDNF） in patients with depression. Methods Serum BDNF levels were measured in 40 depression and 48 healthy controls. The severities of depression were measured with the 17--item Hamilton Rating Scale for Depression （HAMD-17）, before and after antidepressant treatment, respectively. Results The participants with depression had lower Serum BDNF levels than the controls （P〈0.01）, and increased significantly at the end of 8 weeks after treatment（P〈0.05）, with decreased HAMD--17（P〈0.01）. It was estimated that the Serum BDNF levels had negative relationship with sex and age（P〈0.05）, whereas no relationship with education, disease duration, and HAMD--17 scores（P〉0.05）. Conclusions The resuits indicate that, compared to antidepressant treatment, the patients with depression prior to treatment have worse executive function performance and lower Serum BDNF.