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分裂症听感觉加工障碍与较高程度功能障碍的关系

The relationship between sensory processing dysfunction and higher-- level dysfunction within the auditory information processing in schizophrenia
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摘要 目的用失匹配负波(MMN)和P300去评定分裂症听信息加工中听感觉加工障碍与较高程度功能障碍的相关性。方法52例分裂症患者和44例正常对照组采用事件相关脑电位检查,测量MMN和P300潜伏期和波幅,并采用SPSS和结构方程模型进行分析。结果患者组产生的MMN的潜伏期、波幅与正常对照组比较差异有统计学意义(t=6.18,P〈0.01;t=2.42,P〈0.05),患者组产生的P300的波幅与正常对照组比较差异有统计学意义(t=2.64,P=0.01),患者组产生的P300的潜伏期与正常对照组比较差异无统计学意义(t=1.71,P〉O.05)。结构方程模型评定显示Group(疾病过程)和MMN波幅及Group和P300波幅显示出有显著路径的内相关(B=-1.01,P=0.015;B=0.60,P=0.039),MMN波幅与P300波幅显示出有显著路径的内相关(B=0.17,P=0.015)。结论分裂症听信息加工中听感觉加工的障碍直接影响着较高程度的功能障碍。
出处 《神经疾病与精神卫生》 2012年第4期395-397,共3页 Journal of Neuroscience and Mental Health
关键词 分裂症 听信息加工 听感觉加工障碍 较高程度的功能障碍 Schizophrenia Auditory information processing Sensory processing dysfunction Higher-- level dysfunction
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