脑梗死急性期血浆纤维蛋白原水平与病情及预后相关性研究

Relationship between plasma fibrinogen level and the prognosis of patients with acute cerebral infarction

目的探讨脑梗死急性期(ACI)患者血浆纤维蛋白原(Fib)水平的改变及其与病情和预后的关系。方法检测250例脑梗死患者(ACI组)和226名健康成人(健康对照组)的血浆Fib含量。在ACI患者入院当天和4周时进行临床神经功能缺损程度评分(NDS)。结果 ACI组血浆Fib水平异常率明显高于健康对照组(44.8%vs.9.3%,P<0.01);NDS重型患者血浆Fib含量[(5.82±1.51)mg/L]明显高于中型[(4.17±1.09)mg/L]、轻型[(4.26±1.15)mg/L]患者(均P<0.01)。血浆Fib含量升高组患者住院4周时显著进步和进步者明显低于Fib正常组(均P<0.01),而无变化和恶化者明显高于Fib正常组(均P<0.01)。结论 ACI患者血浆Fib水平均明显升高,病情重的患者升高更明显,血浆Fib含量升高的患者预后较差。

Objective To explore and compare the clinical value of plasma fibrinogen（Fib） in evaluating the prognosis of acute cerebral infarction（ACI）.Methods The plasma Fib levels of 250 cerebral infarction patients（ACI group） and 226 health adults（NC group） were measured.All patients were scored at the first day and the fourth week by clinical neurological function deficit scores（NDS） when admitted hospital.Results The levels of plasma Fib in the ACI group were higher than that of the NC group（P0.01）.The levels of plasma Fib in the patients of NDS in heavy duty were higher than that in the medium duty and slight-duty patients（P0.01）.The significant improvement ratio and degree in the group with abnormal plasma Fib levels was lower than that in the normal group at the fourth week（P0.01）.Conclusion Plasma fibrinogen level could reflect the severity and prognosis of the disease.The prognosis of ACI patients with high fibrinogen level should be worse.