依折麦布联合应用阿托伐他汀治疗高胆固醇血症的疗效和安全性

The efficacy and safety of ezetimibe combined with atorvastatin for treating of hypercholesterolemia

目的观察依折麦布联合阿托伐他汀钙对高脂血症患者降脂的疗效与安全性。方法选择原发性高胆固醇患者171例,随机分为3组,依折麦布组、阿托伐他汀钙组和依折麦布与阿托伐他汀联用组(联用组)进行12周的治疗。分别使用10 mg/d依折麦布、不同剂量阿托伐他汀钙、10 mg/d依折麦布与不同剂量阿托伐他汀钙联合治疗,比较三组患者治疗前后的血脂参数的变化率、血脂达标率及不良反应发生率。结果治疗后联用组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)有进一步下降,其中TC、LDL-C的变化率与依折麦布组、阿托伐他汀钙组比较,差异有统计学意义(P<0.01);联合用药的调节程度与阿托伐他汀钙的剂量无关(P>0.05),联用组疗效明显高于依折麦布组、阿托伐他汀钙组。不良反应发生率三组间差异无统计学意义(P>0.05)。结论依折麦布联合阿托伐他汀钙具有较好的调节胆固醇代谢的作用,优于单独使用,其安全性较好。

Objective To observe the efficacy and safety of Ezetimibe combined with atorvastatin in treating hyperlipidemia.Methods 171 cases with hypercholesterolemia（an average age of 78 years） were randomly divided into three groups,A（Ezetimibe） group,B（atorvastatin calcium） group and C（Ezetimibe combined with atorvastatin） groups for 12 weeks of treatment.Results There were significant differences between group C and group A,B in TC、LDC-C level after treatment;the effective rate in group C was higher them those in group A and B.There was no significant difference in adverse reaction among the groups.Conclusions The efficacy of combination of ezetimibe and atorvastatin is significantly better than either alone in treating hypercholesterolemia with good safely.