急性心肌梗死患者血浆纤维连接蛋白变化及临床意义

Alteration and clinical significance of plasma Fn levels in patients with acute myocardial infarction

目的探讨急性心肌梗死(AMI)患者血浆中的纤维连接蛋白(Fn)随时间的变化规律,及其与AMI的关系和临床意义。方法选取AMI患者21例作为研究组,采用酶联免疫吸附法分别检测患者心肌梗死后不同时间段外周血浆Fn的水平。并且与健康成人(对照组23例)做对比分析。结果 AMI患者在发病(6.25±2.98)h后血浆中Fn的水平明显低于对照组[(102.51±31.52)mg/L vs.(229.47±20.67)mg/L,P<0.05)],在(16.17±2.14)h后血浆中Fn的水平明显高于对照组[(299.48±106.55)mg/L vs.(229.47±20.67)mg/L,P<0.05]。结论血浆中Fn的水平变化与急性心肌梗死的发生和发展密切相关。其对预测及诊断AMI具有一定临床意义。

Objective To observe the variation of the levels of the plasma fibronectin in patients with AMI,and explore the relation between the its variation and AMI.Methods Patients（n=21） who were diagnosed as AMI were selected,the levels of Fn in plasma from different times were assayed by enzyme-linked immunosorbent assay（ELISA）.The level of Fn in plasma from AMI was compared with that in control group（n=23）.Results The level of Fn in patients with AMI（at 6.25±2.98 hour） was lower than that in control group（n=23）[（102.51±31.52）mg/L vs.（229.47±20.67）mg/L（P0.05）].The level of Fn in patients with AMI（at 16.17±2.14 hour） was higher than that in control group[（299.48±106.55）mg/L vs.（229.47±20.67 mg/L）（P0.05）].Conclusion The level of plasma Fn in patients with acute myocardial infarction is closely related to the occurrence and development of this disease.Plasma Fn has some clinical signification in the prediction and diagnosis of AMI.