Toll样受体2和4在老年慢性左心力衰竭中的表达被引量：1

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摘要目的探讨Toll样受体2(TLR2)和T0ll样受体4(TLR4)在老年慢性左心力衰竭患者外周血单核细胞表面的表达。方法根据NYHA心功能分级和左室射血分数(LVEF)将健康对照者和慢性左心力衰竭患者分成对照组、心功能I级、Ⅱ级、Ⅲ级和Ⅳ级组。采用流式细胞仪检测外周血单核细胞表面TLR2和TLR4的表达。结果左心力衰竭患者不同心功能组中TLR2和TLR4的表达均显著高于对照组(均P<0.05),且随着心功能分级的升高而明显上升。LVEF随着心功能分级的升高而逐渐下降,且与对照组比较,均P<0.05。结论 TLR2和TLR4可能作为一种危险因素参与老年慢性左心力衰竭的发生发展。

作者郭燕李侠杨海晨

机构地区江苏淮安市第二人民医院老年科

出处《中国临床保健杂志》 CAS 2012年第4期412-413,共2页 Chinese Journal of Clinical Healthcare

关键词心力衰竭充血性 TOLL样受体2 TOLL样受体4 危险因素老年人

分类号 R541.61 [医药卫生—心血管疾病]

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