摘要
目的观察替吉奥单药治疗晚期非小细胞肺癌近期疗效及毒副作用。方法 42例晚期非小细胞肺癌患者,均口服单药替吉奥,80mg/(m2·d),每日2次,连服28天,休息14天,6周为1疗程。化疗2疗程后观察疗效和毒副反应。结果可评价疗效病例42例,总有效率(CR+PR)21.43%,CR0例,PR9例,稳定15例。其中初治患者的有效率为28.57%(2/7),复治患者有效率为20.00%(7/35);临床受益率57.14%(24/42)。主要不良反应为厌食、恶心、呕吐、皮肤色素沉着、白细胞减少等。结论替吉奥单药治疗晚期疗效非小细胞肺癌较好,毒副反应能耐受,临床受益率高。
Objective To evaluate the short term activity and toxicity of S-1 in patients with advanced non-small cell lung carc-er. Methods 42 patients with advanced non-small cell lung carcinoma were treated with S-1 80mg / （ m2 ·d） from day 1 to day 28following a 2-week rest. Cycles were repeated every 6 weeks and the effects were evaluated at least 2 cycles. Results All the pa-tients were eligible. There were 9 PR,15 SD. The overall response rate was 21. 43% ,and the response rate for chemotherapy naiveand pretreated patients were 28. 57% （ 2 /7） and 20. 00% （ 7 /35） . The clinical benefit rate was 57. 14% （ 24 /42） . The major toxici-ties were anorexia,nausea,vomiting,skin pigmentation and leucopenia. Conclusion The results of this study demonstrate that S-1has good efficacy and favorable toxicity for patients with advanced non-small cell lung carcinoma.
出处
《中国老年保健医学》
2012年第4期99-100,共2页
Chinese Journal of Geriatric Care
关键词
晚期非小细胞肺癌
替吉奥
化疗
Advanced non-small cell lung cancer
S-1
chemotherapy
