同型半胱氨酸、颈动脉粥样硬化与脑梗死复发的关系

Relationship between homocysteine,carotid atherosclerosis and recurrent cerebral infarction

目的探讨脑梗死复发与血同型半胱氨酸以及颈动脉粥样硬化程度的关系。方法对50例复发脑梗死患者和51例未复发脑梗死患者进行颈动脉超声检查以及同型半胱氨酸水平测定,对2组同型半胱氨酸水平和颈动脉粥样硬化的程度进行比较。结果复发组同型半胱氨酸水平显著高于未复发组,2组比较差异有统计学意义(P<0.01);复发组颈动脉中重度硬化22例,未复发组6例,2组比较差异有统计学意义(P<0.01);Logistic回归分析示颈动脉中重度硬化与脑梗死复发呈正相关。结论同型半胱氨酸以及颈动脉粥样硬化程度与脑梗死复发密切相关,颈动脉中重度硬化是脑梗死复发的危险因素,可作为脑梗死复发的预测指标。

Objective To investigate the relationships among homocysteine,the degree of carotid atherosclerosis and recurrent cerebral infarction. Methods The level of homocysteine was determined and carotid Doppler ultrasonography was detected in 50 patients with recurrent cerebral infarction and 51 patients without recurrent cerebral infarction. The level of homocysteine ahd the degree of carotid atherosclerosis were compared between the two groups. Results The level of hbmocysteine in recurrence group was higher than that in without recurrence group, the difference was statistically significant （P〈0. 05）;22 cases with moderate to severe carotid atherosclerosis in recurrence group were found,6 cases in without recurrence group,the difference was statistically significant （P〈0.01）. Logistic regression analysis showed that the moderate to severe carotid atherosclerosis was positively related to the recurrence of cerebral infarction. Conclusion There is a positive relationship between homocysteine,the degree of carotid atheroselerosis and recurrent cerebral infarction. The moderate to severe carotid atherosclerosis is a risk factor of recurrent cerebral infarction and may he a risk predictor in recurrent cerebral infarction.