3-(4-氯苯基)-1,3-2H-3-苯基恶唑[3,4-a]吲哚合成

Synthesis of 3-(4-chlorophenyl)-1, 3-2H-3-phenyloxazoleindole

以溴化亚铜作催化剂,DMF作溶剂,用N-(o-alkynylphenyl)imines亚胺在温和条件下环合-加成反应,一步合成吲哚衍生物,结果发现恶唑类吲哚在不同催化剂、不同底物种类及反应条件下的反应速度和产率具有较大差异性.

Using cuprous bromide as catalyst, DMF as solvent, indole derivatives are get from N-（o-alkynylphenyl）imines by one step cyclization-addition reaction under mild conditions. Results show that the reaction rate and yield of oxazolidinone indole have great differences under different catalysts, substrate types and reaction conditions.