中药杀胚化瘀方联合米非司酮保守治疗异位妊娠的应用研究

Application research of treating EP by the Shapei Huayu recipe plus mifepristone

目的:探讨中药杀胚化瘀方联合米非司酮保守治疗异位妊娠的疗效。方法:2005年7月～2012年3月本院收治的异位妊娠符合保守治疗条件的患者250例随机平均分为两组:研究组125例口服中药杀胚化瘀方1周,联合米非司酮口服3d;对照组125例单次肌肉注射甲氨喋呤,24h后联合米非司酮口服。观察比较两组治疗成功率、药物毒副反应、患侧输卵管再通率及妊娠情况。结果:两组治疗成功率无明显差异(P>0.05);而消化系统、骨髓造血系统并发症及肝功损害发生率研究组明显低于对照组(P<0.05),患侧输卵管通畅率、宫内妊娠率研究组明显高于对照组(P<0.05),再次异位妊娠发生率研究组较对照组为低。结论:中药杀胚化瘀方联合米非司酮保守治疗异位妊娠效果较好,药物毒副作用轻,输卵管再通率及宫内妊娠率高,值得在临床推广应用。

Objective： To explore the clinical efficacy of the Shapei Huayu recipe plus mifepristone on treating ectopic pregnancy （EP）. Methods： From July 2005 to March 2012, ectopic pregnancy in line with conservative treatment of patients with conditions of 250 cases were randomly divided into two groups： The study group of 125 cases were treated by the Shapei Huayu recipe （one week） plus mifepristone （3 days）. The control group was given intramuscular methotrexate therapy, after 24 hours plus mifepristone. Success rate of treatment, medicine toxicity, ipsilateral fallopian tube recanalization rate and pregnancy conditions of the two groups were observed and compared. Results： Both treatment success rate was no significant difference （P〉0.05）; the digestive system, complications of bone marrow hematopoietic system and liver damage incidence of the study group were significantly lower than that of the control group （P〈0.05）. Ipsilateral tubal patency, intrauterine pregnancy rate of the study group were significantly higher （P〈0.05）, the incidence of ectopic pregnancy of the study group was lower. Conclusion： The Shapei Huayu recipe plus mifepristone was effective in treating EP, medicine side effects of light, and fallopian tube recanalization rate and intrauterine pregnancy rate, worthy of clinical application.