同型半胱氨酸水平与冠状动脉病变的相关性分析

Correlation of Homocysteine Levels and Coronary Artery Disease

目的:探讨并分析血浆同型半胱氨酸(HCY)水平与冠状动脉病变的关系及与其他危险因素的相关性,以探讨其在冠心病发生、发展中的意义与地位。方法:选择2010年9月-2011年9月在心内科住院并行冠状动脉造影检查的患者50例为观察组,与对照组30例用酶联免疫分析法测定血浆HCY浓度,检测血糖(GLU)、血脂、C反应蛋白(CRP)、脑钠肽(BNP),同时行冠状动脉造影记录状动脉现变支数、狭窄程度。结果:随着冠脉病变支数的增多,血浆HCY水平呈上升趋势,其中单支病变组高于对照组,两组比较差异有统计学意义(P<0.05)。三支病变组高于双支病变组,两组比较差异有统计学意义(P<0.05)。结论:同型半胱氨酸水平与冠状动脉病变相关,静脉血同型半胱氨酸可替代动脉血同型半胱氨酸作为诊断冠心病及复杂程度的指标之一。冠状动脉不同病变程度与血浆HCY水平有明显关系,可作为冠状动脉病变的一个危险因素,HCY越高冠状动脉发病率越高。

Objective： To study and analyze plasma homocysteine （HCY） levels, coronary artery lesion, and other risk factors to explore in coronary heart disease, the development of the meaning and status. Method： In the hospital from September 2010 to September 2011, Department of Cardiology, inpatient concurrent coronary angiography and 50 patients with the control group （30 cases）, using enzyme-linked immunosorbent assay determination of plasma HCY levels, blood glucose（GLU） lipids, C-reactive protein（CRP）, brain sodium peptide（BNP）, coronary angiography records arteries now change the count, the degree of stenosis. Result： CHD group, plasma HCY levels （34.69±10.31）μmol/L was significantly higher than （9.57± 2.57）μmol/L（P〈0.01）. Upward trend with the increase of the number of coronary lesions, plasma HCY levels, including single-vessel disease group than that in the non-CAD group, the difference was statistically significant（P〈0.05）. There was significant difference between three-vessel disease group and the double-vessel disease group（P〈0.05）. Conclusion： Homocysteine levels and coronary heart disease, blood homocysteine can replace arterial blood with homocysteine as the diagnosis of coronary heart disease and complexity of one of the indicators. Different coronary lesion extent and plasma HCY levels, can be used as a risk factor for coronary artery disease, HCY higher the high rate of coronary incidence.