GP方案联合鸦胆子油乳一线治疗晚期非小细胞肺癌的临床研究

Clinical study of bruceolic oil emulsion combined GP program in treatment of advanced nonsmall-cell lung cancer

目的探讨GP方案联合鸦胆子油乳对初治晚期非小细胞肺癌（NSCLC）患者的近期疗效和不良反应。方法136例初治晚期NSCLC患者按随机数字表法分成两组，每组68例，对照组给予GP方案化疗，化疗4个疗程；观察组在对照组基础上给予鸦胆子油乳30ml加入0．9％氯化钠250m1静脉滴注，每天1次，30d为1个疗程，共4个疗程，比较两组的近期疗效及不良反应。结果观察组近期客观有效率为32．4％（22，68），对照组为17．6％（12，68），两组比较差异有统计学意义（P〈0．05）。观察组近期主观有效率为52．9％（36／68），对照组为32．4％（22，68），两组比较差异有统计学意义（P〈0．05）。两组治疗前CD3＋、CD4＋、CD8＋、CD56＋比较差异无统计学意义（P〉O．05），观察组治疗后CD3＋、CD4＋、CD8＋、CD56＋显著优于对照组（0．552±0．072比0．468±0．080、0．368±0．062比0．288±O．061、O．268±0．052比0.212±0．044、0．226±O．044比0．168±0．042），两组比较差异有统计学意义（P〈O．05）。两组Ⅲ＋Ⅳ度不良反应比较差异无统计学意义（P〉0．05）。结论GP方案联合鸦胆子油乳治疗晚期NSCLC有协同作用，并且可以减轻化疗不良反应。

Objective To evaluate the clinical efficacy, untoward reaction of bruceolic oil emulsion combined GP program in treatment of advanced non-small-cell lung cancer （NSCLC）. Methods One hundred and thirty-six patients with NSCLC were divided into observation group and control group with 68 cases each by random digits table,the two groups were received GP program, the observation group added bruceolic oil emulsion （1 time a day）. The effective rate and untoward reaction between two groups were compared. Results The objective effective rates of observation group and control group were 32.4% （22/68） and 17.6%（12/68） ,the subjective effective rates of observation group and control group were 52.9%（36/68） and 32.4% （22/68）,there were significant differences between two groups （P 〈0.05）. There was no significant difference in CD3＋, CD4＋, CD8＋, CD56＋ between two groups before treatment （P 〉 0.05 ）. CD3＋, CD4＋, CD8＋,CD56＋ in observation group were better than those in control group after treatment （0.552 ± 0.072 vs. 0.468 ± 0.080,0.368 ± 0.062 vs. 0.288 ± 0.061,0.268 ± 0.052 vs. 0.212 ± 0.044,0.226 ± 0.044 vs. 0.168 ± 0.042 ）, there were significant differences between two groups （P 〈 0.05 ）. There was no statistical difference in Ⅲ ＋ IV degree untoward reaction between two groups （P 〉 0.05）. Conclusion Better therapeutic efficacy and less untoward reaction are expected by combined bruceolic oil emulsion with GP program in treatment of advanced NSCLC.