肺癌组织中P53和Ki-67的表达及意义

Expression and clinical significance of P53 and Ki-67 in lung cancer

目的观察P53和Ki-67在肺癌组织中的表达状况及其与病理和临床特征的意义。方法采用免疫组织化学SP法检测233例肺癌组织中P53和Ki-67的表达，结合临床资料进行分析。结果肺癌组织巾P53和Ki-67的阳性表达率分别为80．7％和99．6％，其中低阳性表达率分别占了阳性表达率的44．2％和57．2％。P53的表达与肺癌组织类型无明显关系，而Ki-67的表达与肺癌组织类型有一定关系，鳞癌以高表达为主，而腺癌与细支气管肺泡癌以低表达为主；P53在淋巴结转移组的阳性表达率为95．0％，高于无淋巴结转移组，而Ki67的表达与淋巴结是否转移无明显关联。结论肺癌组织中P53和Ki67阳性表达率高，但低阳性表达的病例占了相当的比例，两者可能共同参与了肺癌的发生、发展，P53与肺癌淋巴结转移的关系可能更大，而Ki67的阳性表达程度与病理类型有关。

Objective To investigate the expression and clinical significance of P53 and Ki-67 in lung cancer tissues. Methods The expressions of P53 and Ki-67 in 233 specimens of lung cancer were detected by SP immunohistochemistry, and were analyzed with clinical data. Results The positive expression rates of P53 and Ki 67 in lung cancer tissue were 80.7% and 99.6% respectively. In those specimens with positive expression of P53 and Ki-67, 44.2% and 57.2% were low level expression respectively. There was no statistical correlation between the P53 expression and histologic type of lung cancer. Unlikely, the positive expression of Ki 67 was high in squamous carcinoma, and was low in adenocarcinoma and abronchioalveolar carcinoma. The expression rate of P53 in lung cancer with metastasis of lymphonodus was 95.0%, higher than that without metastasis. But the expression rate of Ki-67 had no relationship with metastasis of lymphonodus. Conclusions The positive expression rates of P53 and Ki-67 in lung cancer tissue are high, but nearly half are at low level. P53 and Ki-67 may involve in the occurrence and development of lung cancer. The expression rate of P53 is more relevant to metastasis of lymphonodus than that of Ki-67, while Ki-67 expression level is more relevant to histologic type of lung cancer.