PCT和CRP测定在新生儿败血症早期诊断中的价值

Value of PCT and CRP determination in early diagnosis of neonatal sepsis

目的评价血清降钙素原（PCT）、C-反应蛋白（CRP）测定在新生儿败血症早期诊断的临床价值。方法对新生儿败血症患儿40例（日龄3～28天）和非败血症患儿（日龄3～28天）40例检测其血清PCT和CRP，并进行回顾性分析。结果两组闻PCT测定阳性率比较有显著性差异（χ2=58．35，P〈0．05），治疗1周后复查PCT，败血症组PCT阳性仅有4例，阳性率占10．0％，与治疗前败血症组阳性率比较有显著性差异（χ2=57．94，P〈0．05）。两组间CRP阳性率比较有显著性差异（χ2=28．03，P〈0．05）。PCT灵敏度与特异度均高于CRP。结论两组间PCT灵敏度和特异度高，可用于判断细菌感染的严重程度、疗效及预后。在早期诊断新生儿败血症时PCT优于CRP。

Objective To evaluate the clinical significance of procalcitonin （PCT） and C-reactive protein （CRP） determination in early diagnosis of neonatal sepsis. Methods Retrospective analysis of serum PCT and CRP in 40 cases of neonatal sepsis （aged 3-28 days） and 40 cases of non neonatal sepsis （aged 3-28 days） was conducted. Results There were significant differences in PCT positive rate between two groups（χ2 =58.35 ,P 〈0.05）. After anti-infection treatment for one week, there were only 4 cases of positive PCT and the positive rate was 10.0% , which was significantly different from that before treatment （χ2 = 57.94, P 〈 0.05 ）. There was significant difference in CRP positive rate between two groups （χ2 = 28.03, P 〈 0. 05 ）. The sensitivity and specificity of PCT were higher than those of CRP. Conclusion The sensitivity and specificity of PCT in two groups are high, and they can be used to determine severity of infection, curative effect and prognosis. PCT is superior to CRP in early diagnosis of neonatal sepsis.