高危型HPV/TCT检测在宫颈疾病筛查中的临床价值

Clinic value of combination of high risk HPV test and ThinPrep liquid-based cytology in cervical screening

目的:探讨高危型HPV(HR-HPV)检测联合宫颈液基细胞学(TCT)检查(HR-HPV/TCT)在宫颈疾病筛查中的临床价值。方法:回顾性分析2008-01-2011-01来我院就诊的自愿接受HR-HPV/TCT检测的患者2140例。对TCT异常和TCT阴性而HR-HPV阳性的患者386例进行阴道镜加活检检查。结果:TCT异常者327例,ASCUS(意义不明宫颈不典型鳞状上皮细胞)196例,LSIL(低度宫颈上皮内病变)93例,HSIL(高度上皮内病变)38例。病理报告炎症156例,宫颈癌前病变(CIN)160例(其中CINⅡ级和Ⅲ级共60例),宫颈癌11例。HR-HPV检出率随宫颈病变级别的增高而上升(P<0.005)。TCT阴性而HR-HPV阳性的患者59例,病理报告炎症29例,CIN27例(CINⅡ级和Ⅲ级共12例),宫颈癌3例。结论:HR-HPV/TCT检测可有效检出宫颈CIN和宫颈癌,减少漏诊率。

Objective：To discussion clinic value of high risk HPV （HR-HPV） testing combined with cervical liquid-based cytology （TCT） in cervical screening. Method：A total of 2 140 patients were tested for HR-HPV de- tection combined with TCT check from January 2008 to January 2011. Three hundred and eighty-six cases of ab- normal and TCT TCT negative HR-HPV positive patients, colposcopy with biopsy examination. Result.-TCT ab- normal in 327 cases, 196 cases of ASCUS. （Of undetermined significance cervical atypical squamous cells）, LSIL （low-grade cervical intraepithelial neoplasia） 93 cases of HSIL （high intra-epithelial lesions of 38 patients）. Patho- logical report on inflammation in 156 cases, CIN160 cases （the which CIN ]I level and Class Ill 60 cases）, 11 ca- ses of cervical cancer. The HR-HPV detection rate increased with the increased level of cervical lesions （P〈0. 005）. TCT negative HR-HPV-positive patients with 59 cases of inflammation of pathology reports of 29 cases, the CIN27 cases （12 cases CIN 11 level and class Ⅲ ）, three cases of cervical cancer. Conclusion.. HR-HPV/TCT detection can be effectively detected in cervical CIN and cervical cancer, reduce the rate of misdiagnosis.