摘要
目的:探索中药参附注射液治疗急性左心衰大鼠疗效对心力衰竭(心衰)指标NT-proBNP的影响。方法:采用急性左心衰大鼠模型,观察单用西药和参附注射液联合西药治疗前后15min、30min、60min和24h小时大鼠NT-proBNP、左室收缩末期压(LVESP)、左室内压最大上升速率(dp/dtmax)的变化。结果:参附注射液联合西药治疗急性左心衰大鼠前后30minNT-proBNP的变化具有统计学意义,联合治疗组优于单纯参附注射液组或单纯西药治疗组。结论:参附注射液对心肌细胞有正性肌力作用,NT-proBNP作为临床中药疗效观察的敏感指标应广泛应用于急性心衰治疗。
Objective：To explore the efficacy of NT-proBNP of acute left ventricular failure rats with the treat- ment of Chinese medicine Shenfu injection. Method：The group of rat model in acute left heart failure, observed the treatment indicators （NT-proBNP, LVESP, dp/dtmax） in sham operation group ,separate Chinese medicine, sep- arate Western medicine and combined group in 15 minutes, 30 minutes, 60 minutes and 24 hours. Result： NT- proBNP is statistically significant in the group of 30 minutes treatment of Shenfu injection combined Western medi- cine rates with acute left ventrieular failures. The efficacy of eomhination therapy group is better than the separate Shenfu injection group and separate Western medicine group. Conclusion： The Shenfu injection has positive ino- tropic effect on myocardial cells. NT-proBNP as a sensitive indicator of the observation in the clinical traditional Chinese medicines and widely used in the observation the efficacy of acute heart failure.
出处
《临床急诊杂志》
CAS
2012年第4期276-278,共3页
Journal of Clinical Emergency
基金
武汉市卫生局科研资助项目(No:WZ11C03)
