摘要
A new compound,3,5-dihydroxy-N-（3-nitrobenzylidene）benzohydrazide （DNBB） methanol solvate,was synthesized and characterized by single-crystal X-ray diffraction.DNBB crystallizes in a monoclinic system,space group P2 1/c with a=8.387（4）,b=23.237（10）,c=9.133（3）,β=122.10（3）o,Z=4,V=1507.8（12） 3,D c=1.464 g/cm 3,F（000）=696.0,μ=0.116 mm-1,the final R=0.0480 and wR=0.1294.DNBB exhibited low toxicity on Caco-2 cell culture and produced significant inhibitory effect on the contraction of rat jejunal longitudinal smooth muscle （JLSM）.The mechanism of DNBB on JLSM was correlated to the stimulation of α and β adrenergic receptors since α receptor antagonist phentolamine and β receptor antagonist propranolol abolished the inhibitory effects of DNBB on the contraction of JLSM,respectively.
A new compound,3,5-dihydroxy-N-（3-nitrobenzylidene）benzohydrazide （DNBB） methanol solvate,was synthesized and characterized by single-crystal X-ray diffraction.DNBB crystallizes in a monoclinic system,space group P2 1/c with a=8.387（4）,b=23.237（10）,c=9.133（3）,β=122.10（3）o,Z=4,V=1507.8（12） 3,D c=1.464 g/cm 3,F（000）=696.0,μ=0.116 mm-1,the final R=0.0480 and wR=0.1294.DNBB exhibited low toxicity on Caco-2 cell culture and produced significant inhibitory effect on the contraction of rat jejunal longitudinal smooth muscle （JLSM）.The mechanism of DNBB on JLSM was correlated to the stimulation of α and β adrenergic receptors since α receptor antagonist phentolamine and β receptor antagonist propranolol abolished the inhibitory effects of DNBB on the contraction of JLSM,respectively.
基金
supported by the National Natural Science Foundation of China (No. 30772601)
