丁苯肽治疗血管性痴呆疗效观察

The Clinical Research of Combination of Butylphthalide and Piracetam in the Treatment of Patients with Vascular Demetia

目的研究丁苯酞对血管性痴呆(VD)患者认知功能的影响、生活能力的改善及安全性。方法选择临床明确诊断为VD的患者62例,随机分为对照组和治疗组,对照组予以常规口服阿司匹林、吡拉西坦治疗,治疗组在以上治疗基础上加用丁苯酞长期口服,以60 d为一个评定周期,两组患者在治疗前及治疗60 d分别对其进行简易智能状态量表(MMSE)和日常生活能力表(ADL)评分,并进行比较,同时评价丁苯肽软胶囊的药物不良反应。结果两组治疗后的MMSE及ADL评分较治疗前均有显著提高(P<0.01),与对照组相比,治疗组治疗后MMSE及ADL评分较对照组改善更为明显,两组治疗后评分比较差异具有统计学意义(P<0.05)。结论丁苯肽联合吡拉西坦治疗血管性痴呆临床有效,能显著改善VD患者的认知功能,且不良反应少。

Objective To research the curative effect of butylphthalide in treating vascular dementia,the improvement of the ability of living and its safety. Methods 62 cases with VD were randomly divided into 2 groups： control group and butylphthalide group ; MMSE and ADL scores were applied to patients in both groups before treatment and after being treated for 60 days,the results were compared;the evaluation of the side-effect of butylphthalide was made at the same time. Results The scores of MMSE and ADL of the patients in both groups after treatment were much higher than those before treatment（ P 〈 0.01 ） ; the scores of butylphthalide group after treatment were improved much more obviously than those of control group（ P 〈 0.01 ）, the difference between the 2 groups was of significance （ P 〈 0.05 ）. Conclusion Butylphthalide was of definite curative effect and of less side effect in treating vascular dementia.