32例妊娠期肝内胆汁淤积症临床分析

Clinical Analysis of 32 Patients with Intrahepatic Cholestasis of Pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)的危害、分娩时机及方式。方法回顾性分析海淀区妇幼保健院2007～2011年收治的32例ICP患者的临床资料。结果 13例患者出现并发症,其中妊娠期高血压3例,重度子痫前期2例,妊娠期糖尿病1例,妊娠期糖耐量受损2例,血小板减少1例,胎儿生长受限1例,胎死宫内1例,羊水污染4例,产后出血1例。轻度ICP患者13例,无羊水污染、胎儿窘迫、胎死宫内发生,早产2例;重度ICP患者19例,早产6例,均因病情严重、合并症/并发症剖宫产分娩。结论轻度ICP可观察至妊足月,在密切监护下行阴道试产,并放宽剖宫产指征。一旦诊断重度ICP,需立即住院,未足月者积极治疗并密切监护,36周左右适时剖宫产终止妊娠。

Objective To investigate the harm of intrahepatic cholestasis of pregnancy（ICP） and the time and manner of delivery in patients with ICP. Methods The clinical data of 32 patients with ICP from 2007 to 2011 in Haidian maternal and child health hospital were analyzed retrospectively. Results There were 13 patients had complications,3 cases were with hypertension in pregnancy,2 with severe pre-eclampsia, 1 with gestational diabetes mellitus,2 with pregnancy impaired glucose tolerance, 1 with thrombocytopenia, 1 with fetal growth restriction, 1 with still birth,4 with amniotic fluid pollution and 1 with postpartum hemorrhage. 13 patients with the mild ICP had no amniotic fluid pollution, fetal distress or still birth. A premature delivery was seen in 2 patients with mild ICP. 6 patients with the severe ICP had premature cesarean section delivery because of serious condition or complications. Conclusion For the patients with mild ICP a full term trial of vaginal labour can be performed under the close monitoring and a relaxed cesarean section indications. The patients with severe ICP should immediately be cared in hospital with closely monitoring and positive treatment. The cesarean section should be timely carried out to terminate the gestation on the 36th weeks.