受血和有偿供血HIV感染患者HAART效果的比较

Comparative study on the effect of highly active antiretroviral therapy （ HAART ） in patients with HIV infection acquired by blood transfusion and paid plasma donation

目的研究受血和有偿供血HIV感染患者的高效抗病毒治疗（HAART）效果。方法病例来自河北省本籍的受血和有偿供血感染的患者。受血感染病例为1995年前后一次性输血感染发病的189例，其中105例接受HAART作为观察组，84例未接受HAART作为对照组。有偿供血感染病例为1995年有偿供血普查发现感染的患者120例，其中63例接受HAART作为观察组，57例未接受HAART作为对照组。发病Et期作为进入队列日期，死于AIDS作为结局事件。进入观察组和对照组的对象定期接受跟踪调查，观察终点2010年12月31日。结果受血和有偿供血感染患者接受HAART组的病死强度分别为4．42／100人年和6．13／100人年，生存期分别为110个月生存80％和90个月生存72％；而未接受HAART的病死强度分别为182．05／100人年和250．66／100人年，平均生存分别为4个月和3个月。结论受血和有偿供血感染患者的HAART效果没有区别，治疗后可降低病死强度并延长存活期。

Objective To study the effect of HAART in patients with AIDS acquire by blood transfusion aiad paid plasma donation. Methods All AIDS patients whose disease was caused by blood transfusion and commercial plasma donation came from the domicile of Hebei Province. In the group of cases of blood transfusion in whom the infection was caused by one-time blood transfusion before and after 1995, there were 189 cases, of whom 105 cases on HAART were designated as observation group, and 84 cases who were not on HAART were designated as control group. The group of AIDS patients who were former commercial plasma donors （FCPDs） had 120 patients who were identified in the survey of 1995, of whom 63 cases on HAART were designated as observation group and 57 cases who were not on HAART were as control group. Onset dates were defined as the dates into the queue. Death due to AIDS was regarded as an outcome event. Sbjects who were enrolled into the observation group and control group were epidemiologically followed up regularly. Observation was ended on December 31, 2010. Results Mortality of patients after HAART from groups of FCPDs and blood recipients were 4.42/100 person-years and 6.13/100 person-years, respectively. The survival rates of HAART groups were 80% in FCPDs for 110 months and 72% in blood recipients for 90 months, respectively. Meanwhile the mortality of no HAART groups were 182.05/100 person-years and 250. 66/100 person-years, respectively. Mean survival of patients whose disease was caused by plasma donation and blood transfusion were 4 months and 3 months, respectively. Conclusions Whether the HIV infection was caused by plasmapheresis or blood transfusion, the effects of HAART did not show difference. HAART cold reduce the death intensity and prolong survival.