肺癌锥形束CT与计划CT形变配准自动勾画危及器官可行性研究

Study the feasibility of kilovolt cone beam CT organs at risk contouring automatically usingdeformation registration in the radiotherapy of lung

目的定量分析肺癌计划CT与千伏级锥形束cT（KVCBCT）应用形变配准软件自动勾画危及器官可行性。方法选取5例肺癌患者1套定位cT图像和各10套摆位验证KVCBCT图像进行形变配准自动勾画和手工勾画危及器官，比较形变配准和刚性配准后的Dice相似性系数（DSC）、敏感性等差异，并行配对t检验。结果形变配准和刚性配准在体表轮廓、左肺、右肺、心脏、脊髓的DSC值分别为0．971和0．980（t=3．89，P=0．000）、0．836和0．873（t=4．41，P=0．000）、0．873和0．888（t=3．88，P=0．000）、0，738和0．764（t=4．83，P=0．000）、0。666和0，677（t=2．04．P=0．047）；敏感性分别为0．975和0．981（f=1．41，P=0．003）、0．914和0．803（t=-6．88，P=0．000）、0．926和0．800（t=-7．06，P=0．045）、0．782和0．708（t=-2．50，P=0．040）、0．625和0．796（t=-9．09，P=0．000）。结论利用形变配准进行器官轮廓自动勾画差异小于刚性配准，体表轮廓、芹右肺形变配准轮廓自动勾面效果优干心脏和脊髓的轮廓自动勾面．

Objective To quantitative analysis the difference of organ contour using planning CT and kilovolt cone beam CT （KVCBCT） deformable registration. Methods One set planning CT image and ten sets of KVCBCT image of one patient were choose and total five patients. Organ contour were automatic outlined to using deformable registration. To compare the organ contours different of deformable registration （DR） and rigid registration （RR）. Statistic analysis was executed with paired t-test for dice similarity coefficient （DSC） value and sensitiveness （SENS） value. Results The DSC value of body, left, right lung, heart and spinal respectively ： 0. 971 and 0. 980 （ t = 3.89, P = 0. 000）, 0. 836 and 0. 873 （ t= 4.41, P = 0. 000 ） ,0. 873 and 0. 888 （ t = 3.88, P = 0. 000 ）, 0. 738 and 0. 764 （ t = 4. 83, P = 0. 000 ）, 0. 666 and 0. 677 （ t = 2. 04, P = 0. 047 ）. The SENS value ： 0. 975 and 0. 981 （ t = 1.41, P = 0. 003 ） , 0. 914 and 0. 803 （t= -6.88,P=0.000）,0.926 and0.800（t= -7.06,P=0.045）,0.782 and0.708（t= -2.50,P= 0. 040） ,0. 625 and 0. 796（t = -9. 09,P =0. 000）. Conclusions RR is at a competitive disadvantage in terms of organ contour outline. The body, left and right lung that are used DR have advantage over the heart and spinal.