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胰岛细胞移植示踪技术的研究进展

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摘要 胰岛细胞移植是治疗1型糖尿病的理想方法,但胰岛细胞经门静脉移植后直接暴露于受试者血液中,各种免疫性和非免疫性攻击导致胰岛细胞大量丢失,由于缺乏有效的监控工具,其机制尚不十分明确。胰岛移植示踪技术则可研究移植后的血管化及免疫攻击过程中移植物及其功能变化,从而客观评价移植细胞在受试者体内的分布、存活和迁徙情况。理想的示踪技术应具备能够监测肝脏中单个胰岛的高分辨率、能简单且正确量化移植的胰岛细胞、要与胰岛功能及胰岛移植效果相关的条件。
作者 秦瑶 张梅
出处 《中华糖尿病杂志》 CAS 2012年第8期493-495,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
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参考文献17

  • 1Borot S,Crowe LA,Toso C. Noninvasive Imaging Techniques in islet Transplantation[J].Current Diabetes Reports,2011.375-383.
  • 2Virostko J,Radhika A,Poffenberger G. Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation[J].Molecular Imaging and Biology,2010.42-53.
  • 3Speier S,Nyqvist D,Cabrera O. Noninvasive in vivo imaging of pancreatic islet cell biology[J].Nature Medicine,2008.574-578.
  • 4Perez VL,Caicedo A,Berman DM. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes:a study in a baboon model of diabetes[J].Diabetologia,2011.1121-1126.
  • 5Lcvitt HE,Cyphert TJ,Pascoe JL. Glucose stimulates human beta cell replication in vivo in islets transplantation into NOD-severe combined immunodeficiency mice[J].Diabetologia,2011.572-582.
  • 6Ding W,Bai J,Zhang J. In vivo tracking of implanted stem cells using radio-labeled transferrin scintigraphy[J].Nuclear Medicine and Biology,2004.719-725.
  • 7Bulte JW,Kraitchman DL. Iron oxide MR contrast agents for molecular and cellular imaging[J].NMR in Biomedicine,2004.484-499.
  • 8Daldrup-Link HE,Rudelius M,Plontek G. Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model:in vivo monitoring with 1.5-T MR imaging equipment[J].Radiology,2005.197-205.
  • 9Jirak D,Kriz J,Herynek V. MRI of transplanted pancreatic islets[J].Magnetic Resonance in Medicine,2004.1228-1233.
  • 10Malosio ML,Esposito A,Poletti A. Improving the procedure for detection of intrahepatic transplanted islets by magnetic resonance imaging[J].American Journal of Transplantation,2009.2372-2382.

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