摘要
目的:观察高强度聚焦超声(High intensity focused ultrasound,HIFU)对肝门部胆管癌(Hilar cholangiocarcinoma,HC)患者机体免疫功能的影响。方法:对32例胆管癌患者经HIFU治疗后,检测治疗前、后外周血T淋巴细胞亚群(CD3+、CD4+、CD8+)、NK细胞活性率及IgG、IgA和IgM滴度的变化。结果:HIFU治疗后CD3+、CD4+、NK细胞活性率明显升高而CD8+水平下降(P<0.05);IgG、IgA和IgM滴度较HIFU治疗前明显升高(P<0.01)。结论:HIFU具有调节胆管癌患者细胞免疫损害状态、克服肿瘤免疫逃逸现象、改善机体免疫功能的作用。
Objective:To observe the effect of high intensity focused ultrasound (HIFU) on immune function of patients with hilar cholangiocarcinoma. Methods:HIFU treatment was performed on 32 patients with hilar cholangiocarcinoma. Tests were carried out to find change of T lymphocyte subsets in peripheral blood(CD3+, CD4+, CDs+), cytoactive rate of NK cells and titcr of IgG, lgA and IgM before and after HIFU treatment. Results : After HIFU treatment, cytoactive rate of CD3+, CD4+.NK were obviously heightened, however, that of CD8+ was descended(P〈0.05). Titer of IgG,IgA and IgM was increased obviously(P〈0.01). Conclusion:HIFU posses some effects in adjusting immune damage in cells, overcoming tumor immunity escaping and improving immune function in organism.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2012年第8期711-713,共3页
Journal of Chongqing Medical University
基金
国家重点基础研究发展计划(973计划)资助项目(编号:2011CB707902)
关键词
高强度聚焦超声
肝门胆管癌
免疫功能
high intensity focused ultrasound (HIFU)
hilar cholangiocarcinoma(HC)
immune function