高强度聚焦超声对肝门部胆管癌患者机体免疫功能的影响

Effect of high intensity focused ultrasound on immune function of patients with hilar cholangiocarcinoma

目的:观察高强度聚焦超声(High intensity focused ultrasound,HIFU)对肝门部胆管癌(Hilar cholangiocarcinoma,HC)患者机体免疫功能的影响。方法:对32例胆管癌患者经HIFU治疗后,检测治疗前、后外周血T淋巴细胞亚群(CD3+、CD4+、CD8+)、NK细胞活性率及IgG、IgA和IgM滴度的变化。结果:HIFU治疗后CD3+、CD4+、NK细胞活性率明显升高而CD8+水平下降(P<0.05);IgG、IgA和IgM滴度较HIFU治疗前明显升高(P<0.01)。结论:HIFU具有调节胆管癌患者细胞免疫损害状态、克服肿瘤免疫逃逸现象、改善机体免疫功能的作用。

Objective：To observe the effect of high intensity focused ultrasound （HIFU） on immune function of patients with hilar cholangiocarcinoma. Methods：HIFU treatment was performed on 32 patients with hilar cholangiocarcinoma. Tests were carried out to find change of T lymphocyte subsets in peripheral blood（CD3＋, CD4＋, CDs＋）, cytoactive rate of NK cells and titcr of IgG, lgA and IgM before and after HIFU treatment. Results ： After HIFU treatment, cytoactive rate of CD3＋, CD4＋.NK were obviously heightened, however, that of CD8＋ was descended（P〈0.05）. Titer of IgG,IgA and IgM was increased obviously（P〈0.01）. Conclusion：HIFU posses some effects in adjusting immune damage in cells, overcoming tumor immunity escaping and improving immune function in organism.