胃肠道间质瘤治疗新方法的探讨

The study of new methods in gastrointestinal stromal tumor therapy

目的探讨胃镜与腹腔镜双镜联合及内镜黏膜下挖除术(endoscopic submucosal excavation,ESE)治疗胃肠道间质瘤的效果和安全性。方法经胃(肠)镜、超声内镜及病理学、免疫组化证实的胃肠道间质瘤患者37例,对其中28例患者采用ESE、9例采用胃镜与腹腔镜双镜联合进行瘤体切除。结果 ESE及双镜联合治疗的所有患者均完整切除瘤体,两种方法均无术中及术后迟发性出血、剧烈腹痛等并发症,瘤体位于贲门者,切除后患者贲门功能保持良好,术后随访无复发。结论胃镜与腹腔镜双镜联合技术及ESE是治疗胃肠道间质瘤的微创、安全、有效的新方法。

Objective To explore the efficacy and safety of laparoscopy combined with endoscopy and endoscopic submueosal excavation （ESE） in gastrointestinal stromal tumor therapy. Methods 37 patients were identified gastroin- testinal stromal tumor by endoscopy, endoscopic uhrasonography, pathology and immunohistochemical methods. 28 pa- tients underwent endoscopic submucosal excavation （ESE） , 9 patients underwent laparoscopy combined with endosco- py. Results The turner was resected completely in all. All patients underwent endoscopic therapy resected the tumor completely. No bleeding and abodminal pain happened during and after the operation. Patient with gastric cardia tumor remained good function after the tumor resection. Conclusion Laparoscopy combined with endoscopy and ESE are mini- real invasive, sate and effective new methods in gastrointestinal stromal tumor therapy.