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血清骨保护素与2型糖尿病下肢血管病变的关系 被引量：1

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摘要 骨保护素（osteoprotegerin,OPG）作为肿瘤坏死因子受体超家族成员,不仅是骨代谢的一个重要调节因子,而且还是一种重要的血管调节因子,目前研究发现OPG是动脉粥样硬化进程及心血管病病死率的独立危险因子。
作者 王竞 荣玉栋
机构地区 天津市人口和家庭公共服务中心计划生育研究所检验科 天津市第一中心医院国际诊疗中心
出处 《临床荟萃》 CAS 2012年第18期1608-1609,共2页 Clinical Focus
关键词 糖尿病 2型 骨保护素 糖尿病血管病变
分类号 R587.1 [医药卫生—内分泌]
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参考文献13

  • 1Bucay N,Sarosi I, Dunstan CR et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification [J]. Genes Dev, 1998,12(9): 1260-1268.
  • 2Min H, Morony S, Sarosi I, et al. Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis[J].J Exp Med, 2000,192 (4) : 463-474.
  • 3Browner WS, Lui LY, Cummings SR. Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fracture,and mortality in elderly women[J]. J Clin Endocrinol Metab,2001,86(2) 1631-637.
  • 4Jono S,Ikari Y,Shioi A,et al. Serum osteopmtegerin levels are associated with the presence and severity of coronary artery disease[J].Circulation,2002,106(10) :1192-1194.
  • 5Schoppet M, Sattler AM, Schaefer JR, et al. Increased osteoprotegerin serum levels in men with coronary artery diseae[J]. J Clin Endoerinol Metab, 2003.88 (3) : 1024-1028.
  • 6Ueland T, Jemtland R, Godang K, et al. Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction[J]. J Am Coll Cardiol, 2004,44(10) : 1970-1976.
  • 7Knudsen ST, Foss CH, Poulsen PL, et al. Increased plasma concentrations of osteoprotegerin in type 2 diabetic patients with microvascular eomplications[J]. Eur J Endocrinol, 2003, 1499(1) :39-42.
  • 8Kim SM, Lee J, Ryu OH, et al. Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity[J].Clin Endocrinol (Oxf), 2005,63(5) 594-598.
  • 9Kiechl S,Schett G,Wenning G, et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease [J]. Circulation, 2004,109 (18) : 2175-2180.
  • 10Kim HH, Shin HS, Kwak HJ, et al. RANKL regulates endothelial cell survival through the phophatidylinositol 3'- kinase/Akt signal transduction pathway[J].FASEB J, 2003,17 (14) :2163-2165.

二级参考文献20

  • 1向光大,何玉生,蒋文,胡泰洪.女性2型糖尿病患者载脂蛋白e4等位基因与内皮依赖性血管舒张功能降低有关[J].中华内分泌代谢杂志,2005,21(1):9-12. 被引量：9
  • 2向光大,陈志松,邓胜平,戴晓婧,王平.1型糖尿病早期肱动脉内皮依赖性血管舒张功能已降低[J].中华内分泌代谢杂志,2005,21(1):18-20. 被引量：12
  • 3Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell, 1997, 89 : 309 -319.
  • 4Dhore CR, Cleutjens JP, Lutgens E, et al. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vas Biol, 2001,21:1998-2003.
  • 5Zhang J, Fu M, Myles D, et al. PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways. FEBS letters, 2002,521 : 180-184.
  • 6Jono S, Ikari Y, Shioi A, et al. Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation, 2002,106 : 1192-1194.
  • 7Schoppet M, Sattler AM, Schaefer JR, et al. Increased osteoprotegerin serum levels in men with coronary artery disease, J Clin Endocrinol Metab, 2003,88 : 1024-1028.
  • 8Knudsen ST, Foss CH, Poulsen PL, et al. Increased plasma concentrations of osteoprotegerin in type 2 diabetic patients with microvascular complications. Eur J Endocrinol, 2003,149:39-42.
  • 9Avignon A, Sultan A, Piot C, et al. Osteoprotegerin is associated with silent coronary artery disease in high-risk but asymptomatic type 2 diabetic patients, Diabetes Care, 2005,28:2176-2180.
  • 10Browner WS, Lui LY, Cummings SR, Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fracture, and mortality in elderly women, J Clin Endocrinol Metab, 2001,86 : 631- 637.

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临床荟萃
2012年 第18期

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