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非小细胞肺癌组织中核糖核苷酸还原酶M1的表达与吉西他滨耐药的关系

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摘要 我国肺癌的发病率逐年上升,目前已排在肿瘤病死率的首位。这些肺癌患者中,有80%以上为非小细胞肺癌(NSCLC),大多数NSCLC患者确诊时已经发展到中晚期,中晚期NSCLC患者多采用以化疗为主的综合治疗,根据生物靶标选择优势人群,
出处 《临床荟萃》 CAS 2012年第18期1633-1635,1657,共3页 Clinical Focus
基金 河北省科学技术研究与发展支撑计划项目(09276121)
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参考文献9

  • 1Gautam A, Li ZR, Bepler G. RRMl-induced metastasis suppression through PTEN-regulated pathways[J]. Oncogene, 2003, 22(14) :2135-2142.
  • 2Rha SY, Jeung HC, Choi YH, et al. An association betweenRRM1 haplotype and gemcitabine- induced neutropenia in breast cancer patients[J]. Oncologist, 2007,12 ( 6 ), 622-630.
  • 3Davidson JD, Ma L, Flagella M, et al. An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines[J]. Cancer Res,2004,64 (11):3761-3766.
  • 4Ceppi P, Volante M, Novello S, et al. ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitahine[J]. Ann Oncol,2006,17(12) : 1818-1825.
  • 5李张云,邓觐云,黄传生,陈悦,周伟华.非小细胞肺癌RRM1蛋白表达与吉西他滨体外药敏相关性的研究[J].江西医药,2009,44(11):1074-1077. 被引量:4
  • 6Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets,and side effects[J].N Engl J Med,2003,348(6): 538-549.
  • 7Bergman AM, Eijk PP, Ruiz van Haperen VW, et al. In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant[J]. Cancer Res,2005,6(20) : 9510-9516.
  • 8Rosell R, Felip E, Taron M, et al. Gene expression as a predictive marker of outcome in stage I1 13-HI A- B non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery[J]. Clin Cancer Res, 2004, 10 (12 Pt 2) : 4215s-4219s.
  • 9吴一龙,周清.核苷酸切除修复系统基因表达水平与化疗药物耐药相关性的系列研究[J].循证医学,2006,6(1):3-6. 被引量:8

二级参考文献9

  • 1廖日强,林嘉颖,乔贵宾,骆新兰,杨衿记,黄玉娟,吴一龙.非小细胞肺癌组织芯片中RRM1表达和预后因子分析[J].中国肺癌杂志,2006,9(5):423-427. 被引量:20
  • 2Goan YG,Zhou B,Hu E,Mi S,et al. Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxy -cytidine in the human KB cancer cell line. Cancer Res, 1999,59, 4204.
  • 3Kurbacher CM ,Cree IA ,Bruckner HW,et al . Use of an ex vivo ATP luminescence assay to direct chemotherapy for recurrent ovarian cancer. Anticancer Drugs ,1998,9(1):51.
  • 4Dumontet C ,Fabianowska-Majewsda K ,Mantincic D ,et al.Common resistance mechanisms to deoxynucleoside analogues in variants of the hum an erythroleukaemic line K562.Br J Haematol,1999, 106(1): 78.
  • 5DavidsonJ D,M aL ,Flagela M ,et al.An increase in the expression of ribonucleotide reductase large subunitl is associated with gemcitabine resistance in non-small cell lung cancer cell lines.Cancer Res ,2004,64(11):3761.
  • 6Bunn P,Lynch TJ,Ettinger TS,et al.Lung Cancer,CCO Independent Conference Coverage of the 2005 Annual Meeting of the ASCO[DB/OL].Clinical Care Options,
  • 7Rosell R,Danenberg KD,Alberola V,et al.Ribonucleotide reductase messenger RNA expression and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients[J].Clin Cancer Res,2004,10:1318-1325.
  • 8Rosell R,Felip E,Taron M,et al.Gene expression as a predictive marker of outcome in stage ⅡB-ⅢA-ⅢB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery[J].Clin Cancer Res,2004,10(suppl 12):S4215-S4219.
  • 9Rosell R,Cobo M,Isla D,et al.ERCC1 mRNA-based randomized phase Ⅲ trial of docetaxel (doc) doublets with cisplatin (cis) or gemcitabine (gem) in stage Ⅳ non-smallcell lung cnncer (NSCLC) patients (p)[J].J Clin Oncol,2005,23(suppl 1):7002.

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