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髓源性抑制细胞——肿瘤免疫治疗的新靶点

Myeloid - derived suppressor cells ： a new target of cancer immunotherapy
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摘要 髓源性抑制细胞（ Myeloid - derived suppressor cells, MDSCs）是在病理情况下扩增的一种髓源性抑制细胞群，其特点是能负向调节机体的抗肿瘤免疫反应从而促进肿瘤的发生和发展。通过阻断MDSCs的免疫抑制通路来提高肿瘤免疫治疗的效果，是一个颇有前景的治疗策略。 Myeloid - derived suppressor cells （MDSCs） are a heterogeneous population of myeloid derived cells Which were amplified in pathological status,which is characterized as negatively regulating the anti -tumor immune response with the result of promoting tumorigenesis and cancer development. It is a promising strategy to enhance the effect of cancer immunotherapy through blocking the immunosuppressive pathway of MDSCs.
作者 武丽华 王东亮(综述) 张艳桥(审校)
机构地区 哈尔滨医科大学附属第三医院内八科 哈尔滨医科大学肿瘤防治研究所
出处 《实用肿瘤学杂志》 CAS 2012年第4期369-372,共4页 Practical Oncology Journal
关键词 髓源性抑制细胞 免疫抑制 肿瘤免疫治疗 Myeloid - derived suppressor cells lmmunosuppression Tumor immunotherapy
分类号 R730.51 [医药卫生—肿瘤]
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  • 1Gabrilovich DI, Nagaraj S. Myeloid - derived suppressor cells as regulators of the immune system [ J ]. Nat Rev Im- muno ,2009,9 ( 3 ) : 162 - 174.
  • 2Delano MJ, Scumpia PO, Weinstein JS, et al. MyD88 - de- pendent expansion of an immature GR -1 CD1 lb popula- tion induces T cell suppression and Th2 polarization in sep- sis [ J]. J Exp Med,2007,204(6) : 1463 - 1474.
  • 3Rodriguez PC, Quiceno DG, Ochoa AC. 1 - arginine availa- bility regulates T- lymphocyte cell- cycle progression [ J ]. Blood ,2007,109 ( 4 ) : 1568 - 1573.
  • 4Bingisser RM, Tilbrook PA, Holt PG, et al. Macrophage - derived nitric oxide regulates T- cell activation via reversi- ble disruption of the Jak3/STAT5 signaling pathway [ J ]. J Immunol, 1998,160(12) :5729 - 5734.
  • 5Dugast AS, Haudebourg T, Coulon F, et al. Myeloid - de- rived suppressor ceils accumulate in kidney allograft toler- ance and specifically suppress effector T cell expansion [ J ]. J Immuno1,2008,180 ( 12 ) : 7898 - 7906.
  • 6Kusmartsev S, Nefedova Y, Yoder D, et al. Antigen - specif- ic inhibition of CD8 + T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species [ J ]. JImmunol, 2004,172 ( 2 ) .989 - 999.
  • 7Hildeman DA, Mitchell T, Aronow B, et al. Control of Bcl - 2 expression by reactive oxygen species [ J 1. Proc Natl Acad Sci USA, 2003,100 ( 25 ) : 15035 - 15040.
  • 8Vickers SM, MacMillan - Crow LA, Green M, et al. Associa- tion of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor trans- formation in pancreatic cancer [ J]. Arch Surg, 1999, 134 (3) :245 -251.
  • 9Ekmekcioglu S, Ellerhorst J, Smid CM, et al. Inducible nitric oxide synthas and nitrotyrosine in human metasitatic melano- ma tumors correlate with poor survival [ j ]. Clin Cancer Res ,2000,6(12) :4768 -4775.
  • 10Sinha P, Clements VK, Ostrand - Rosenberg S. Interleukin - 13 - regulated M2 macrophages in combination with mye- loid suppressor cells block immune surveillance against me- tastasis [ J ]. Cancer Res,2005,65 (24) : 11743 - 11751.
实用肿瘤学杂志
2012年 第4期

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