CBS催化硼烷胺配合物不对称还原法制备(S)-3-氯-1-苯基-1-丙醇

Asymmetric Synthesis of(S)-3-Chloro-1-phenyl-1-propanol Using Borane Amine Complex-CBS as Catalyst

分别以R-α,α-二苯基脯氨醇、(1R,2S)-2-氨基-1,2-二苯基乙醇和(1R,2S)-(-)-1-氨基-2-茚醇为催化剂,以多种硼烷胺配合物为还原剂,由β-氯代苯乙酮不对称合成(S)-3-氯-1-苯基-1-丙醇,收率88.3%～93.8%,e.e.值为81.6%～87.7%。用硼烷胺配合物代替硼烷-THF和硼烷二甲硫醚,稳定性好,容易计量和安全操作。

（S）-3-Chloro-1-phenyl-1-propanol was synthesized asymmetrically by using catalysts （R）-α,α-diphenyl-2-pyrrolidinemethanol, （1R,2S）-2-amino-1,2-diphenylethanol and （1R,2R）-1-amino-2-indanol with amine borane complexes, with a yield of 88.3%~93.8%, ee% 81.6~87.7. These amine borane complexes are more stable and safe than the borane-tetrahydrofuran complex and borane-methyl sulfide complex.