白芷的化学成分研究

CHEMICAL CONSTITUENTS OF ANGELICA DAHURICA

目的:研究白芷Angelica dahurica的化学成分。方法:采用硅胶柱色谱、Sephadex LH-20、重结晶等方法进行化学成分的分离纯化,采用光谱法鉴定其结构。结果:从白芷75%乙醇提取物的乙酸乙酯萃取部位分离鉴定了14个化合物,分别为水合氧化前胡内酯(Ⅰ)、比克白芷素(Ⅱ)、异氧化前胡内酯(Ⅲ)、Oxypeucedanin hydrate acetonide(Ⅳ)、珊瑚菜内酯(Ⅴ)、异欧前胡素(Ⅵ)、7H-Furo[3,2-g][1]benzopyran-7-one,9-me-thoxy-4-(3-methyl-2-oxobutoxy)-(Ⅶ)、佛手柑内酯(Ⅷ)、花椒素酚(Ⅸ)、neobyakangelicol(Ⅹ)、豆甾醇(Ⅺ)、胡萝卜苷(Ⅻ)、硬脂酸()、棕榈酸()。结论:化合物Ⅶ为首次从该属中分离得到,化合物I～X均为线性呋喃香豆素衍生物。

objective：To study the chemical constituents from the dry root of Angelica dahurica. Methods：Compounds were isolated by C -18 column,Sephadex LH -20. Their structures were eluci- dated by spectral analysis. Results：Fourteen compounds wereisolated and their structures were identi- fied as oxypeucedanin （ Ⅰ ）, byakangelicin （ Ⅱ ）, isooxypeucedanin （ Ⅲ ）, oxypeucedanin hydrate ace- tonide （ Ⅳ ）, phellopterin （ Ⅴ ）, isoimperatorin （ Ⅵ ）,7 H - Furo [ 3,2 - g ] [ 1 ] benzopyran - 7 - one, 9 - methoxy - 4 - （ 3 - methyl - 2 - oxobutoxy） - （ Ⅶ ）, bergapten （ Ⅷ ）, xanthotoxol （ Ⅸ ）, neobyakangeli- col（ Ⅹ ）, stigmasterol （ Ⅺ ） , daucosterol （ Ⅻ ）, stearic acid （ ⅩⅢ ） , palmitic acid （ ⅩⅣ ）. Conclusion： The compound Ⅶ was isolated form Angelica dahurica for the first time.