摘要
目的:采用静息态功能磁共振成像(resting-state functional MRI,rfMRI)技术,探讨正常人静息态下脑低频振幅(amplitude of low frequency fluctuation,ALFF)的性别差异。方法:对19例男性健康者与19例年龄、受教育程度相匹配的女性健康者进行磁共振静息态扫描,使用ALFF算法对比分析MRI数据,观察男女性血氧水平依赖(blood oxygenation level dependent,BOLD)信号振荡幅度不同的区域。结果:较女性健康组,男性健康组双侧中央前回、双侧额中回、双侧颞上回区域的ALFF值更高;较男性健康组,女性健康组左丘脑、左角回、右海马旁回、后扣带回、脊髓小脑区域的ALFF值更高。结论:静息态下正常人的脑神经活动存在性别差异。
Objective:To study the amplitude of low frequency fluctuation (ALFF) at the resting state fMRI in healthy men and women, and discussed its underlying neuro -pathophysiological mecha- nism. Methods :The resting state fMRI data of 19 men and 19 women who performed ALFF were anal- ysis. The amplitude of the blood oxygenation level dependent (BOLD) activation of the resting state brain was investigated. The brain structures having ALFF increase and decrease were demonstrated. Results :The ALFF increased and decreased symmetrically in the brain regions. The increased involve- ment of men located in bilateral precentral gyrus, bilateral middle frontal gyrus and bilateral superior temporal gyms. The increased involvement of women covered the limbie system such as parahippocam- pal gyrus, posterior cingulate gyrus; the spinal cord cerebellum,etc. Conclusion:There are sex differ- ences of nervous activity at resting state.
出处
《内蒙古医学院学报》
2012年第4期289-293,共5页
Acta Academiae Medicinae Neimongol
基金
内蒙古医学院青年创新基金(NY2011QN013)
关键词
静息态功能磁共振成像
性别差异
低频振幅
Resting - state functional MRI
Sex differences
Amplitude of low frequency fluctua- tion