皮肤渗透性实验优选消肿散涂膜剂组方

OPTIMIZATION THE FORMULA OF XIAOZHONGSAN PAINT BY PERCUTANEOUS PERMEABILITY EXPERIMENT

目的:以大黄酸为测定指标,采用皮肤渗透性实验优选消肿散涂膜剂组方。方法:正交设计涂膜剂的配方,采用改进的Franz扩散池,用离体大鼠皮进行体外透皮作用研究,薄层色谱扫描法测定透皮接受液中大黄酸的含量。结果:最佳配方为3号组方(基质6%;氮酮6%;药液浓度0.5g生药/mL)且大黄酸累积透过量随透皮时间延长而增加。结论:本优选方法为消肿散涂膜剂的配方研究提供了参考。

Objective： To research the percutaneous process of rhein in the XIAOZHONGSAN paint, and select the optimal formula of paint. Methods： The formula of paint was made by the orthogo- nal design, and utilizing modified Franz diffusion cells, the content of rhein in the transdermal receptive liquid was determined by Dual -Wave thin layer chromatogram scanner with excised rat skin. The ac- cumulation permeation amounts and permeation rate of rhein were calculated. Results：The optimal for- mula is as following：matrix 6% ;Azone 6% ;0. 5g/mL drug concentration. The percutaneous penetration of rhein is increased by the transdermal time. Conclusion：The reference data of the XIAOZHONGSAN paint formula was provided by this optimization study.