牙齿脱落与女性椎体压缩性骨折风险相关性研究

The Risk Correlation Study of Tooth Loss and Female Vertebral Compression Fractures

目的:分析牙齿脱落与椎体压缩骨折的关系,评估牙齿脱落是否可以用作预测椎体压缩骨折风险的指标。方法:简易问卷调查保定市骨科医院住院治疗的椎体压缩骨折病人,所有个体均为绝经后女性,调查项目包括牙齿脱落年龄,脱落数目,骨折发生时情况,骨质家族史,有无服用糖皮质激素药物史等。研究共纳入符合条件的骨折组126人,对照组102人。牙齿脱落率、牙齿脱落年龄和牙齿脱落个数对骨折风险的影响采用多因素logestic回归模型分析。结果:骨折组牙齿脱落率显著高于对照组,平均牙齿脱落年龄显著低于对照组,骨折前牙齿脱落的数量显著低于对照组;多因素Logistic回归分析显示,校正骨折家族史后,牙齿脱落与骨折风险显著相关[OR=3.598,95%CI(1.917,6.753)];年龄小于59岁发生牙齿脱落的个体以及牙齿脱落大于4颗的个体,骨折风险可能进一步显著增加[OR=5.092,95%(2.451,10.578);OR=2.656,95%(1.350,5.225)]。结论:牙齿过早脱落与椎体压缩骨折风险高度相关,其临床应用前景尚需大样本前瞻性研究来证实。

Objective：To analysis the relationship tooth loss and vertebral compression fractures,determine whether tooth loss could be used as a risk index for predicting vertebral compression fractures.Methods：A simple questionnaire was used to investigate vertebral compression fractures patients hospitalization in Osteopathic Hospitals of Baoding city,all patients were post-menopause female,Survey items included the age of tooth loss,loss number,the situation of fracture,Family history of osteoporosis and whether taking corticosteroid drugs.The patients of Meeting the fracture conditions were 126 cases,control group included 102 cases.A multivariate Logestic regression analysis was used to evaluate the effect of tooth loss rate、loss age、loss number on vertebral compression fractures.Results：Compared with control group,Tooth loss rate of vertebral compression fractures was higher,tooth loss age was obviously lower than control group,tooth loss number before fracture was obviously less than control group.Multivariate logistic regression analysis demonstrated that there was a notable positive correlation between tooth loss and vertebral compression fractures after correction of a family history of fractures[OR=3.828,95% CI（1.904,7.694）].And,individual with tooth loss age less than 59 years and loss more than 4 teeth had a higher fracture risk[OR=5.092,95%（2.451,10.578）;OR= 2.656,95%（1.350,5.225）].Conclusion：There is a notable positive correlation between tooth loss and vertebral compression fractures risk,the clinical application prospect needs large prospective study to confirm.