化学法制备赤藓糖的研究

Study on the chemical processes of preparing of erythrose

赤藓糖是一种带有还原性醛基的四碳糖,在常规条件下结构不稳定,可通过加氢反应进一步制备赤藓糖醇。化学法制备赤藓糖的成功打破了赤藓糖醇行业目前仅由发酵法来实现的局限,对行业整体生产成本的降低具有重要的意义。本文所提的工艺是用葡萄糖酸钠配成溶液,在搅拌及一定的温度条件下,以六水氯化钴为催化剂,通过双氧水氧化制备赤藓糖。先通过单因素试验确定了葡萄糖酸钠的浓度、六水氯化钴和双氧水的用量、反应温度、双氧水加入时间等条件的变化曲线。通过正交实验筛选出葡萄糖酸钠氧化制备赤藓糖的最佳工艺条件,即六水氯化钴添加量为葡萄糖酸钠质量的1.4%、双氧水添加量和葡萄糖酸钠质量相同、葡萄糖酸钠溶液的浓度10%、氧化温度控制在40℃、在此最佳工艺条件下葡萄糖酸钠氧化为赤藓糖的转化纯度为59.9%。

Erythroseis a four - carbon sugar with a reducing aldehyde, and is unstable. Through hydrogenation reac- tion, itcan be used in the production oferythritol. This chemical process has broken the traditional fermentation erythri- tol industry. It costs less and has significant influence in erythritol industry. The technology uses cobalt chloride hexa- hydrate as a catalyst, sodium gluconate solution reacts with hydrogen peroxide under stirring and certain temperature to prepare erythrose. Single -factor test determined the concentration of sodium gluconate, cobalt chloride hexahydarte, hydrogen peroxide, reaction temperature and time. The relationship between the above factors and the yields of erythrose were showed in the diagrams. Base on orthogonal design experiment, the optimal pretreatment conditionis as follows： CoC12 ~ 6H20 content is 1.4% of sodium gluconate, hydrogen peroxide content is the same to the weight of sodium gluconate, the solution concentration of sodium gluconate is 10%, the reaction temperature is 40℃. The maxi- mumerythrose yield （59.9%） isobtained under the aboveconditions.