姜黄素及其衍生物体内抗炎活性的研究

Anti-Inflammation Effect of Curcumin and Its Derivatives in Vivo

目的研究姜黄素及其衍生物体内抗炎活性。方法通过建立二甲苯致小鼠耳廓肿胀和角叉菜胶致小鼠足肿胀炎症模型,探讨姜黄素及其衍生物体内抗炎作用;观察姜黄素及其衍生物对前列腺素E2,总抗氧化能力,丙二醛的影响。结果与模型组相比,姜黄素及其衍生物对二甲苯致小鼠耳廓肿胀和角叉菜胶致小鼠足肿胀有不同程度的改善(P<0.05,P<0.01);与模型组相比,姜黄素及其衍生物不同程度的降低血浆中丙二醛含量、升高总抗氧化能力含量和降低炎症组织中前列腺素E2的含量(P<0.05,P<0.01)。结论姜黄素及其衍生物皆有抗炎的活性,其抗炎活性可能与其提高小鼠体内抗氧化能力和抑制炎症组织内前列腺素E2的合成有关。

OBJECTIVE To investigate the anti-inflammation effect of curcumin and its derivative in vivo. METHODS Observations were made on the anti-inflammatory effect of curcumin and its derivatives in xylene-induced mouse ear edema and carrageenaninduced paw edema. The plasma T-AOC, MDA and tissue PGE21evels were measured. RESULTS Xylene-induced mouse ear edema and earrageenan-induced paw edema were improved by curcumin and its derivatives in different degrees （ P 〈 0. 05, P 〈 0. 01 ） , the plasma MDA levels were lowered, the T-AOC levels were increased, meanwhile PGE2 synthesis in the inflammatory tissues were inhibited （ P 〈 0. 05, P 〈 0. 01 ）. CONCLUSION The anti-inflammatory activity of curcumin and its derivatives in mice may be related to increasing antioxidant capacity and inhibiting the PGE2 synthesis.