雌激素受体α在小鼠海马中的表达研究

Investigation on Expression of Estrogen Receptor Alpha in Mouse Hippocampus

雌激素在生殖系统、认知记忆系统、骨骼和神经的发育及其功能维持等多种生理功能中扮演了重要的作用。雌激素可以通过结合到核雌激素受体Erα、Erβ来完成其生理功能。最近通过ER敲除鼠和选择性的抑制剂研究表明Erα在海马中具有重要作用。Erα在海马中的表达是否具有年龄和性别差异的研究较少,该文研究了Erα在不同年龄、不同性别的小鼠海马中的表达,并进一步比较了Erα在卵巢去除小鼠和对照小鼠中的表达差异。研究结果揭示了Erα在海马中的表达具有年龄和性别差异,暗示了Erα的表达受到外周雌激素水平的调控。这些结果为进一步研究雌激素和Erα在海马组织中基因表达的调控过程以及相关疾病的临床治疗提供参考。

The sex hormone estrogen is a hormonal multi-tasker, contributing to roles as diverse as the differentiation and function of the reproductive tract, memory storage, bone growth and nerve system. Estrogens exert many of their be- havioral effects by binding to nuclear estrogen receptor Erα and Erβ. Recent studies involving ER knockout mice and se- lective ER agonists suggest that ER α playsan important role in hippocampal function. Little is known about whether the expression of Erα is related to aging and gender. In this paper, the expression of Erα was examined in mice hippocam- pus between age, sex and OVX difference. The data suggest that the expression of Erα is relatedto aging and gender and imply that the expression of Erα is regulated by peripheral estrogen. These results provide a reference for further study that Erα involves gene expression regulation of hippocampus and clinical therapy of related diseases.