大剂量辛伐他汀对血脂和颈动脉粥样斑块的影响

Effect of high-dose simvastatin on serum lipids and carotid artery plaque

目的观察辛伐他汀大、小剂量对高脂血症和颈动脉粥样斑块患者血脂和Crouse斑块积分变化的影响，评价大剂量辛伐他汀临床治疗高脂血症和动脉粥样硬化的疗效。方法选择符合病例选择标准的患者60例，随机分为治疗组和对照组，治疗组每晚口服辛伐他汀片80mg，对照组每晚口服辛伐他汀片20mg，疗程共20周。治疗前后分别彩超检测Crouse斑块积分、血脂相关指标。并通过实验室检查确定大剂量辛伐他汀服药的安全性。结果临床研究显示，Crouse斑块积分明显下降（P=0．032），治疗组与对照组相比，治疗组可以明显降低血脂，减少Crouse斑块积分，其疗效优于小剂量对照组（P=0．021）。结论大剂量服用辛伐他汀片具有稳定颈动脉粥样斑块，降低血脂水平的作用，其疗效明显优于小剂量对照组治疗，且临床用药安全。

Objective To observe the effect of simvastatin with small dose and large dose on serum lipid and Crouse plaque integral in patients with hyperlipidemia and carotid artery plaque, and to evaluate the clinical efficacy of high-dose simvastatin on hyperlipidemia and atherosclerosis. Methods Sixty patients with hyperlipidemia and carotid artery plaque were divided into treatment group and control group. Patients in treatment group received simvastatin 80 mg per night, oral; and patients in control group received simvastatin 20 mg per night, the course was 20 weeks. The Crouse plaque integral, lipids and other related indicators were detected by color Doppler ultrasound before and after treatment, the safety of high-dose simvastatin medication was determined by laboratory tests. Results clinical trials showed that Crouse plaque integral and lipid level significantly decreased （ P = 0. 032）. Compared with the control group, the treatment group can significantly lower blood lipids, reduce the Crouse plaque score, and its efficacy was better than control group （P = 0. 021 ）. Conclusions High doses of simvas- tatin tablets has the effect of stabilizing carotid plaque and reducing lipid levels, and its efficacy is signifi- cantly better than control group, and it is safe.