探讨血清组织多肽特异性抗原与骨桥蛋白联合细针穿刺细胞学诊断早期乳腺癌的价值

Value of the serum TPS, OPN combined with fine needle aspiration cytology in the diagnosis of early breast cancer

目的探讨血清组织多肽特异性抗原（TPS）、骨桥蛋白（OPN）联合细针穿刺细胞学诊断早期乳腺癌的价值。方法收集212例拟诊早期乳腺癌患者的血清肿瘤标记物TPS、OPN和细针穿刺细胞学检查资料，并与手术病理作对照，进行回顾性统计分析。结果TPS诊断乳腺癌的敏感性为59．9％（109／182），特异性为90．0％（27／30）；OPN敏感性为62．1％（113／182），特异性为83．3％（25／30）；细针穿刺细胞学检查敏感性为72．5％（132／182），特异性为96．7％（29／30）；三项联合检查敏感性为92．3％（168／182），特异性为76．7％（23／30）。联合检查与单一方法检查相比敏感性明显提高，阳性检出率差异有统计学意义（P〈0．01）。结论对临床疑为早期乳腺癌患者应用血清肿瘤标记物联合细针穿刺细胞学检查是发现早期乳腺癌的有效途径，具有较高的检出率和可靠的诊疗指导意义。

Objective To investigate the diagnostic value of serum tumor makers throttle position sensor （TPS）, Osteopontin （OPN） combined with fine needle aspiration cytology on diagnosis of early breast cancer. Methods The examination material of serum tumor markers TPS, OPN and fine needle as- piration biopsy cytology of 212 patients with early-stage breast cancer were collected. It was compared with surgery pathology and analyzed retrospectively. Results The sensitivity of rIPS was 59. 9% （ 109/182）, specificity was 90. 0% （27/30） ; The sensitivity of OPN was 62. 1% （ 113/182 ）, specificity was 83.3% （25/30） ;The sensitivity of fine needle aspiration cytology was 72. 5% （ 132/182）, specificity was 96. 7% （29/30） ; The sensitivity of the three combined detection was 92. 3% （ 168/182）, specificity was 76. 7% （23/30）. The sensitivity of combined detection was higher than any of them. There were sighificant differ- ences in differences of positive rate （P 〈 0. 01 ）. Conclusions Serum markers detection combined with fine needle aspiration cytology for early breast cancer patients with.clinical suspicion is an effective way for early breast cancer detection. It has high rate of diagnosis and reliable guidance significance for diagnosis and treatment of early breast cancer.