p53、DCC、APC在结直肠癌组织中的表达及其意义

Expression and significance of p53, DCC and APC gene in colorectal carcinoma tissue

目的探讨p53、结直肠癌缺失基因（DCC）和腺瘤性息肉病基因（APC）三种抑癌基因在结直肠癌组织中的表达及其意义。方法采用免疫组织化学方法检测p53、DCC和APC在结直肠癌中的表达。结果结直肠癌中p53高表达，阳性率为68％；结直肠癌中DCC低表达，阳性率为27％；结直肠癌中APC低表达，阳性率为52％。应用检验的关联性分析，癌组织中的DCC基因的表达与APC基因表达呈正相关关系。结论DCC的表达降低与APC的表达降低具有协同作用，p53、DCC和APC的多个基因表达的联合检测可能为判断结直肠癌恶性转化、临床病理过程及预后提供参考依据，具有一定的价值。

Objective To investgate the expression and significance of p53, dreleted in colorec- tal cacinoma（DCC） and adenomatous polyposis coli（APC） gene in colorectal carcinoma. Methods The expression of p53, DCC and APC gene in colorectal cancer was examined by immunohistochemical tech- nique. Results The expressions rate of p53, DCC and APC gene in colorectal carcinoma was 68% , 27% and 52%. There was a positive correlation of the expression of DCC with APC gene （ P 〈 0.05 ）. There was no correlation between the expression of p53 and DCC gene, the expression of DCC and APC gene （P 〉 0.05）. Conclusions The over expression of p53 and the reduced ex- pression of DCC, APC gene was regarded as progonostic factors for colorectal cancers. Combined de- tection of p53, DCC and APC expression is useful in predicting the metastasis potential and prognosis of coloreetal cancer.