一种化学污染物微流控芯片实时检测系统的设计

Design of a microfluidic chip based real-time detection system for chemical pollutants

根据化学事故应急救援与处置现场环境污染快速、实时检测需要,提出了一种化学污染物微流控芯片实时检测系统的设计方案,进行了系统的总体设计和细化设计,论述了系统设计涉及的复杂基质样品微流控芯片预处理技术,特别是固相萃取样品预处理技术、快速灵敏的微流控芯片检测技术、微流控芯片的模拟仿真、设计、集成与控制技术,以及便携式微流控芯片分析仪器的硬件设计和软件开发技术等关键技术及其研究方法,探讨了微流控芯片分离与检测单元的设计与实验、复杂基质样品的微流控芯片预处理单元设计与实验、原理性样机的研制与实验、微流控分析检测方法库和数据库的建立等系统设计的主要研究工作内容及其技术途径。通过微流控芯片分析检测系统包括样品预处理、混合、分离等单元,检测器单元,控制系统和信息处理单元的科学设计,可构建高度集成化、便携化、微型化的微流控分析检测系统,使系统具有适合小分子化合物等环境污染物的分析检测架构。

A microfluidic chip based chemical pollutants real-time detection system is designed according to the rapid real-time environmental pollution detection requirements for chemical accident in site rescue and disposal. Both overall design and detailed design of the detection system is presented. The main key technology and their corresponding research strategy for the design of the microfluidic chip based detection system is discussed, including complex sample pretreatment technology especially solid phase extraction （SPE）, rapid and sensitive detection technology, simulation, design, integration and control technology, and the hardware design and software programming of portable microfluidic chip based analysis instrument. The main research task and their related technological roadmap for the design and test of microfluidic chip based separation and detection unit, complex sample pretreatment unit, the development and test of prototype system, and the building of analysis knowledge base and database is explored. Through the scientific design of sample pretreatment unit, mixing unit, separation unit, detection unit, control unit and information treatment unit, a high integrative, portable, miniature microfluidic chip based analysis and detection system could be successfully designed for the analysis and detection of environmental chemical pollutants.