叶黄素干预对早期老年黄斑变性患者生活质量的影响

CHANGES IN VISION-RELATED QUALITY OF LIFE FOLLOWING LUTEIN SUPPLEMENTS IN EARLY AGE-RELATED MACULAR DEGENERATION PATIENTS

目的研究叶黄素干预对早期老年黄斑变性(aged-related macular degeneration,AMD)患者生活质量的影响。方法采用随机双盲空白对照法,将108名早期AMD患者随机分为叶黄素低剂量组、叶黄素高剂量组、叶黄素/玉米黄素混合干预组和安慰剂对照组,连续服药48 w。于服药0 w及48 w,进行一般情况、膳食营养摄入状况、最佳矫正视力和视功能相关生存质量测定。结果早期AMD患者整体健康状况、总体视力及近距离活动能力显著下降,且总体视力、近距离活动能力分别与矫正视力呈显著正相关。服用叶黄素后最佳矫正视力和视力得分较用药前呈上升趋势;叶黄素/玉米黄素混合用药组近距离活动能力得分较服药前显著提高(P<0.05)。基线视力、活动受限程度分别与其在用药期间的改变呈负相关。结论叶黄素干预可提高早期AMD患者视力水平,并显著改善其近距离活动能力,提示叶黄素对早期AMD患者生活质量具有一定的保护作用。[营养学报,2012,34(4):327-331]

Objectives To investigate the changes in vision-related quality of life following lutein supplements in patients with early age-related macular degeneration（AMD）.Method One hudred and eight early AMD patients were randomly divided into low dosage lutein group,high dosage lutein group,lutein/zeaxanthin group,and placebo group.Patients took lutein and lutein/zeaxanthin compound supplements for 48 w.The levels of general characteristics,dietary intakes,letters of best corrected visual acuity and vision-related quality of life were measured at week 0 and 48.Results The general health,general vision acuity,and near activities of early AMD patients declined significantly.The best corrected visual acuity had significantly positive relationship with general vision acuity and near activities.The best corrected visual acuity and general vision acuity were improved in lutein supplementation groups,whereas significant increase of near activities in lutein/zeaxanthin group（P0.05）.The baseline general vision acuity,and near activities were negatively correlated with the changes from baseline during intervention.Conclusion Vision acuity was improved in early AMD patients,especially for near activities after lutein and zeaxanthin supplementation,suggesting that lutein may have protective role in life quality for early AMD patients.