维生素D与阿尔茨海默病

Vitamin D and Alzheimer＇s disease

老年人普遍存在维生素D缺乏，这可能是阿尔茨海默病（AD）的重要发病机制之一。由于维生素D具有免疫调节、抗氧化、调节神经营养因子、神经递质乙酰胆碱和清除β淀粉样蛋白肽以及避免甲状旁腺功能亢进的功能，能同时针对几种导致神经退行性病变因素发挥作用，特别是老年人纠正维生素D缺乏可能会阻止神经元的损失和与AD相关的认知能力下降，因此补充维生素D可能成为AD多靶向药物治疗的方法。

Vitamin D deficiency is common among the elderly, which may be an important pathogenic factor in Alzheimers disease （AD）. Vitamin D has multiple functions including immune regulation, anti-oxidation, regulation of neurotrophic factors/acetylcholine neurotransmitters, and clearance of amyloid beta peptide; meanwhile, it may be helpful to avoid hyperparathyroidism. Vitamin D supplementation among the elderly may prevent the loss of neurons and slow down the AD-related cognitive decline, and therefore may play a role in the multi-targeted therapies for AD.