三磷酸腺苷结合盒转运体A1基因R219K多态性与冠心病相关性的荟萃分析

Correlation between ATP ABCA1 gene R219K polymorphism and coronary heart disease in Chinese populations

目的研究中国人群ATP结合盒转运体A1(ABCA1)基因R219K多态性与冠心病的相关性。方法计算机检索CBM、CNKI、万方数据库、VIP及Medline、PubMed等数据库,收集中国人群ABCA1基因R219K多态性与冠心病相关性的病例对照研究,检索时间从建库(CBM:1978;CNKI 1994;万方数据库:1989年;VIP:1989年;Medline:1966年;PubMed:2000年)至2012年2月。在评价纳入研究质量并提取有效数据后,用RevMan 5.0软件进行Meta分析。结果纳入13个文献,冠心病2363例,对照人群2328例。K等位基因较R等位基因(OR=0.66,95%CI:0.60～0.71,P<0.01)、携带RK+KK较RR基因型(OR=0.60,95%CI:0.53～0.68,P<0.01)、RK较RR基因型(OR=0.67,95%CI:0.59～0.76,P<0.01)、KK较RR基因型(OR=0.45,95%CI:0.38～0.53,P<0.01)人群发生冠心病的风险更低。结论中国人群ABCA1基因R219K多态性与冠心病的发生、发展有一定关联,而ABCA1的K等位基因是冠心病的保护因素。

Objective To study the correlation between ATP-binding cassette transporter A1 （ABCA1） gene R219K polymorphism and coronary heart disease（CHD） in Chinese populations. Methods Case-control studies on correlation between ABCA1 gene R219K polymorphism and CHD in Chinese populations were searched from CBM, CNKI, Wangfang, VIP, Medline, and PubMed from 1978,1994,1989,1989,1966,2000 respectively to February 2012. Academic level of the included studies was assessed. Meta-analysis of the valid data extracted from the studies was performed using the RevMan 5.0 software. Results Thirteen case-control studies involving 2363 CHD patients and 2328 control subjects were included in this study. The risk to develop CHD waslower in subjects carrying K and R alleles（OR = 0.66,95 % CI.0. 60- 0.71, P〈0.01）, RK＋KK and RR genotypes（OR=0.60,95%CI..0.53--0.68,P〈0.01）,RK and RR genotypes（OR=0.67, 95%CI.0.59--0. 76,P〈0.01）, KK and RR genotypes（OR=0.45,95%CI. 0. 38--0.53,P〈0.01） than in controls. Conclusion ABCA1 gene R219K polymorphism is related with the occur- rence and progress of CHD in Chinese populations and K allele is a protection factor for CHD.